Effect of charcoal-broiled beef on phenacetin metabolism in man

E. J. Pantuck, K. C. Hsiao, A. H. Conney, W. A. Garland, A. Kappas, K. E. Anderson, A. P. Alvares

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37 Scopus citations

Abstract

When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its half-life in the plasma was not changed. The data suggest that feeding charcoal-broiled beef enhances the metabolism of orally administered phenacetin in the intestine or during its first pass through the liver, or both.

Original languageEnglish (US)
Pages (from-to)1055-1057
Number of pages3
JournalScience
Volume194
Issue number4269
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

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    Pantuck, E. J., Hsiao, K. C., Conney, A. H., Garland, W. A., Kappas, A., Anderson, K. E., & Alvares, A. P. (1976). Effect of charcoal-broiled beef on phenacetin metabolism in man. Science, 194(4269), 1055-1057. https://doi.org/10.1126/science.982059