Effect of charcoal-broiled beef on phenacetin metabolism in man

E. J. Pantuck, K. C. Hsiao, A. H. Conney, W. A. Garland, A. Kappas, Karl Anderson, A. P. Alvares

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its half-life in the plasma was not changed. The data suggest that feeding charcoal-broiled beef enhances the metabolism of orally administered phenacetin in the intestine or during its first pass through the liver, or both.

Original languageEnglish (US)
Pages (from-to)1055-1057
Number of pages3
JournalScience
Volume194
Issue number4269
StatePublished - 1976
Externally publishedYes

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Phenacetin
Charcoal
Intestines
Half-Life
Volunteers
Liver
Red Meat

ASJC Scopus subject areas

  • General

Cite this

Pantuck, E. J., Hsiao, K. C., Conney, A. H., Garland, W. A., Kappas, A., Anderson, K., & Alvares, A. P. (1976). Effect of charcoal-broiled beef on phenacetin metabolism in man. Science, 194(4269), 1055-1057.

Effect of charcoal-broiled beef on phenacetin metabolism in man. / Pantuck, E. J.; Hsiao, K. C.; Conney, A. H.; Garland, W. A.; Kappas, A.; Anderson, Karl; Alvares, A. P.

In: Science, Vol. 194, No. 4269, 1976, p. 1055-1057.

Research output: Contribution to journalArticle

Pantuck, EJ, Hsiao, KC, Conney, AH, Garland, WA, Kappas, A, Anderson, K & Alvares, AP 1976, 'Effect of charcoal-broiled beef on phenacetin metabolism in man', Science, vol. 194, no. 4269, pp. 1055-1057.
Pantuck EJ, Hsiao KC, Conney AH, Garland WA, Kappas A, Anderson K et al. Effect of charcoal-broiled beef on phenacetin metabolism in man. Science. 1976;194(4269):1055-1057.
Pantuck, E. J. ; Hsiao, K. C. ; Conney, A. H. ; Garland, W. A. ; Kappas, A. ; Anderson, Karl ; Alvares, A. P. / Effect of charcoal-broiled beef on phenacetin metabolism in man. In: Science. 1976 ; Vol. 194, No. 4269. pp. 1055-1057.
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