Effect of charcoal-broiled beef on phenacetin metabolism in man

E. J. Pantuck; K. C. Hsiao; A. H. Conney; W. A. Garland; A. Kappas; K. E. Anderson; A. P. Alvares

doi:10.1126/science.982059

Effect of charcoal-broiled beef on phenacetin metabolism in man

E. J. Pantuck
, K. C. Hsiao
, A. H. Conney
, W. A. Garland
, A. Kappas
, K. E. Anderson
, A. P. Alvares

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its half-life in the plasma was not changed. The data suggest that feeding charcoal-broiled beef enhances the metabolism of orally administered phenacetin in the intestine or during its first pass through the liver, or both.

Original language	English (US)
Pages (from-to)	1055-1057
Number of pages	3
Journal	Science
Volume	194
Issue number	4269
DOIs	https://doi.org/10.1126/science.982059
State	Published - 1976
Externally published	Yes

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title = "Effect of charcoal-broiled beef on phenacetin metabolism in man",

abstract = "When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its half-life in the plasma was not changed. The data suggest that feeding charcoal-broiled beef enhances the metabolism of orally administered phenacetin in the intestine or during its first pass through the liver, or both.",

author = "Pantuck, \{E. J.\} and Hsiao, \{K. C.\} and Conney, \{A. H.\} and Garland, \{W. A.\} and A. Kappas and Anderson, \{K. E.\} and Alvares, \{A. P.\}",

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doi = "10.1126/science.982059",

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T1 - Effect of charcoal-broiled beef on phenacetin metabolism in man

AU - Pantuck, E. J.

AU - Hsiao, K. C.

AU - Conney, A. H.

AU - Garland, W. A.

AU - Kappas, A.

AU - Anderson, K. E.

AU - Alvares, A. P.

PY - 1976

Y1 - 1976

N2 - When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its half-life in the plasma was not changed. The data suggest that feeding charcoal-broiled beef enhances the metabolism of orally administered phenacetin in the intestine or during its first pass through the liver, or both.

AB - When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its half-life in the plasma was not changed. The data suggest that feeding charcoal-broiled beef enhances the metabolism of orally administered phenacetin in the intestine or during its first pass through the liver, or both.

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UR - https://www.scopus.com/pages/publications/0017297793#tab=citedBy

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DO - 10.1126/science.982059

M3 - Article

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AN - SCOPUS:0017297793

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SP - 1055

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JO - Science

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ER -

Effect of charcoal-broiled beef on phenacetin metabolism in man

Abstract

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