Effect of chronic cocaine treatment on D2 receptors regulating the release of dopamine and acetylcholine in the nucleus accumbens and striatum

A. N. Gifford, K. M. Johnson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The inhibition of electrically stimulated [3H]DA and [14C]ACh release by a submaximal concentration of quinpirole was measured 1 week after pretreating rats for 9 days with cocaine (15 mg/kg IP, twice per day). Although this pretreatment significantly enhanced behavioral response to a challenge injection of cocaine when compared with rats pretreated with saline only, no significant differences were apparent in the degree of inhibition of electrically evoked [3H]DA or [14C]ACh release by quinpirole in either the nucleus accumbens or striatum. In addition, the potentiation of electrically evoked [3H]DA release and corresponding inhibition of [14C]ACh release by 10 μM cocaine, measured in striatal slices only, was not significantly different between the two treatment groups. These results suggest that the enhanced behavioral response resulting from chronic cocaine treatment (behavioral sensitization) is not caused by a subsensitivity of D2 terminal autoreceptors or by a supersensitivity of postsynaptic D2 receptors on cholinergic neurons.

Original languageEnglish (US)
Pages (from-to)841-846
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume41
Issue number4
DOIs
StatePublished - 1992

Fingerprint

Nucleus Accumbens
Cocaine
Acetylcholine
Dopamine
Quinpirole
Rats
Corpus Striatum
Autoreceptors
Cholinergic Neurons
Therapeutics
Cholinergic Agents
Neurons
Injections

Keywords

  • Acetylcholine
  • Autoreceptor
  • Behavioral sensitization
  • Cocaine
  • D receptor
  • Dopamine

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effect of chronic cocaine treatment on D2 receptors regulating the release of dopamine and acetylcholine in the nucleus accumbens and striatum. / Gifford, A. N.; Johnson, K. M.

In: Pharmacology, Biochemistry and Behavior, Vol. 41, No. 4, 1992, p. 841-846.

Research output: Contribution to journalArticle

@article{7504ae87d6f74ae88e1d2e313e667a02,
title = "Effect of chronic cocaine treatment on D2 receptors regulating the release of dopamine and acetylcholine in the nucleus accumbens and striatum",
abstract = "The inhibition of electrically stimulated [3H]DA and [14C]ACh release by a submaximal concentration of quinpirole was measured 1 week after pretreating rats for 9 days with cocaine (15 mg/kg IP, twice per day). Although this pretreatment significantly enhanced behavioral response to a challenge injection of cocaine when compared with rats pretreated with saline only, no significant differences were apparent in the degree of inhibition of electrically evoked [3H]DA or [14C]ACh release by quinpirole in either the nucleus accumbens or striatum. In addition, the potentiation of electrically evoked [3H]DA release and corresponding inhibition of [14C]ACh release by 10 μM cocaine, measured in striatal slices only, was not significantly different between the two treatment groups. These results suggest that the enhanced behavioral response resulting from chronic cocaine treatment (behavioral sensitization) is not caused by a subsensitivity of D2 terminal autoreceptors or by a supersensitivity of postsynaptic D2 receptors on cholinergic neurons.",
keywords = "Acetylcholine, Autoreceptor, Behavioral sensitization, Cocaine, D receptor, Dopamine",
author = "Gifford, {A. N.} and Johnson, {K. M.}",
year = "1992",
doi = "10.1016/0091-3057(92)90236-9",
language = "English (US)",
volume = "41",
pages = "841--846",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Effect of chronic cocaine treatment on D2 receptors regulating the release of dopamine and acetylcholine in the nucleus accumbens and striatum

AU - Gifford, A. N.

AU - Johnson, K. M.

PY - 1992

Y1 - 1992

N2 - The inhibition of electrically stimulated [3H]DA and [14C]ACh release by a submaximal concentration of quinpirole was measured 1 week after pretreating rats for 9 days with cocaine (15 mg/kg IP, twice per day). Although this pretreatment significantly enhanced behavioral response to a challenge injection of cocaine when compared with rats pretreated with saline only, no significant differences were apparent in the degree of inhibition of electrically evoked [3H]DA or [14C]ACh release by quinpirole in either the nucleus accumbens or striatum. In addition, the potentiation of electrically evoked [3H]DA release and corresponding inhibition of [14C]ACh release by 10 μM cocaine, measured in striatal slices only, was not significantly different between the two treatment groups. These results suggest that the enhanced behavioral response resulting from chronic cocaine treatment (behavioral sensitization) is not caused by a subsensitivity of D2 terminal autoreceptors or by a supersensitivity of postsynaptic D2 receptors on cholinergic neurons.

AB - The inhibition of electrically stimulated [3H]DA and [14C]ACh release by a submaximal concentration of quinpirole was measured 1 week after pretreating rats for 9 days with cocaine (15 mg/kg IP, twice per day). Although this pretreatment significantly enhanced behavioral response to a challenge injection of cocaine when compared with rats pretreated with saline only, no significant differences were apparent in the degree of inhibition of electrically evoked [3H]DA or [14C]ACh release by quinpirole in either the nucleus accumbens or striatum. In addition, the potentiation of electrically evoked [3H]DA release and corresponding inhibition of [14C]ACh release by 10 μM cocaine, measured in striatal slices only, was not significantly different between the two treatment groups. These results suggest that the enhanced behavioral response resulting from chronic cocaine treatment (behavioral sensitization) is not caused by a subsensitivity of D2 terminal autoreceptors or by a supersensitivity of postsynaptic D2 receptors on cholinergic neurons.

KW - Acetylcholine

KW - Autoreceptor

KW - Behavioral sensitization

KW - Cocaine

KW - D receptor

KW - Dopamine

UR - http://www.scopus.com/inward/record.url?scp=0026605679&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026605679&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(92)90236-9

DO - 10.1016/0091-3057(92)90236-9

M3 - Article

VL - 41

SP - 841

EP - 846

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 4

ER -