Effect of chronic ingestion of a prostaglandin E analogue on immunologic function in healthy elderly subjects

James Goodwin, George A. Clay

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The immunologic effects of an oral prostaglandin E1 (PGE1) analogue were tested in 25 individuals over age 65, compared to 25 individuals given placebo. Elderly subjects were chosen because previous in vitro studies had found an increased sensitivity to PGE of lymphocytes in older subjects. After 2 weeks of ingestion of PGE analogue or placebo, there was a small but statistically significant decrease in IgM-rheumatoid factor in the PGE analogue group compared to control and a significant decrease in the in vitro sensitivity of lymphocytes from the PGE analogue group to inhibition by PGE. There were no differences in total lymphocyte count, T cell or T cell subset count, delayed hypersensitivity skin test reactivity, serum immunoglobulins, or response to mitogens between the two groups. Administration of an oral PGE analogue to normal elderly individuals is not associated with any detrimental effects on immunologic function after 2 weeks.

Original languageEnglish (US)
Pages (from-to)867-873
Number of pages7
JournalInternational Journal of Immunopharmacology
Volume8
Issue number8
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Synthetic Prostaglandins E
Prostaglandins E
Healthy Volunteers
Eating
Placebos
Lymphocytes
Synthetic Prostaglandins
Rheumatoid Factor
Alprostadil
Delayed Hypersensitivity
Lymphocyte Count
T-Lymphocyte Subsets
Skin Tests
Mitogens
Immunoglobulin M
Oral Administration
Immunoglobulins
Cell Count
T-Lymphocytes
Serum

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

@article{9a99cfeefcb244eca5a8eecb5b1a6be8,
title = "Effect of chronic ingestion of a prostaglandin E analogue on immunologic function in healthy elderly subjects",
abstract = "The immunologic effects of an oral prostaglandin E1 (PGE1) analogue were tested in 25 individuals over age 65, compared to 25 individuals given placebo. Elderly subjects were chosen because previous in vitro studies had found an increased sensitivity to PGE of lymphocytes in older subjects. After 2 weeks of ingestion of PGE analogue or placebo, there was a small but statistically significant decrease in IgM-rheumatoid factor in the PGE analogue group compared to control and a significant decrease in the in vitro sensitivity of lymphocytes from the PGE analogue group to inhibition by PGE. There were no differences in total lymphocyte count, T cell or T cell subset count, delayed hypersensitivity skin test reactivity, serum immunoglobulins, or response to mitogens between the two groups. Administration of an oral PGE analogue to normal elderly individuals is not associated with any detrimental effects on immunologic function after 2 weeks.",
author = "James Goodwin and Clay, {George A.}",
year = "1986",
doi = "10.1016/0192-0561(86)90086-X",
language = "English (US)",
volume = "8",
pages = "867--873",
journal = "International Immunopharmacology",
issn = "1567-5769",
publisher = "Elsevier",
number = "8",

}

TY - JOUR

T1 - Effect of chronic ingestion of a prostaglandin E analogue on immunologic function in healthy elderly subjects

AU - Goodwin, James

AU - Clay, George A.

PY - 1986

Y1 - 1986

N2 - The immunologic effects of an oral prostaglandin E1 (PGE1) analogue were tested in 25 individuals over age 65, compared to 25 individuals given placebo. Elderly subjects were chosen because previous in vitro studies had found an increased sensitivity to PGE of lymphocytes in older subjects. After 2 weeks of ingestion of PGE analogue or placebo, there was a small but statistically significant decrease in IgM-rheumatoid factor in the PGE analogue group compared to control and a significant decrease in the in vitro sensitivity of lymphocytes from the PGE analogue group to inhibition by PGE. There were no differences in total lymphocyte count, T cell or T cell subset count, delayed hypersensitivity skin test reactivity, serum immunoglobulins, or response to mitogens between the two groups. Administration of an oral PGE analogue to normal elderly individuals is not associated with any detrimental effects on immunologic function after 2 weeks.

AB - The immunologic effects of an oral prostaglandin E1 (PGE1) analogue were tested in 25 individuals over age 65, compared to 25 individuals given placebo. Elderly subjects were chosen because previous in vitro studies had found an increased sensitivity to PGE of lymphocytes in older subjects. After 2 weeks of ingestion of PGE analogue or placebo, there was a small but statistically significant decrease in IgM-rheumatoid factor in the PGE analogue group compared to control and a significant decrease in the in vitro sensitivity of lymphocytes from the PGE analogue group to inhibition by PGE. There were no differences in total lymphocyte count, T cell or T cell subset count, delayed hypersensitivity skin test reactivity, serum immunoglobulins, or response to mitogens between the two groups. Administration of an oral PGE analogue to normal elderly individuals is not associated with any detrimental effects on immunologic function after 2 weeks.

UR - http://www.scopus.com/inward/record.url?scp=0022974750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022974750&partnerID=8YFLogxK

U2 - 10.1016/0192-0561(86)90086-X

DO - 10.1016/0192-0561(86)90086-X

M3 - Article

VL - 8

SP - 867

EP - 873

JO - International Immunopharmacology

JF - International Immunopharmacology

SN - 1567-5769

IS - 8

ER -