Effect of D-amino acids on some mitochondrial functions in rat liver

J. C. González-Hernández, L. Aguilera-Aguirre, V. Pérez-Vázquez, J. Ramírez, M. Clemente-Guerrero, C. Cortés-Rojo, A. Saavedra-Molina

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (ΔΨ) was decreased in the presence of 1 μM Ca2+. The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalAmino Acids
Volume24
Issue number1-2
StatePublished - Mar 2003
Externally publishedYes

Fingerprint

Mitochondrial Swelling
Mitochondria
Liver
Swelling
Rats
Liver Mitochondrion
Amino Acids
Oxygen Consumption
Membrane Potentials
Oxygen
D-Aspartic Acid
Rotenone
Oxidative stress
Succinic Acid
Alanine
Methionine
Serine
Free Radicals
Tyrosine
Arginine

Keywords

  • D-Amino acids
  • Free radicals
  • Liver
  • Membrane potential
  • Mitochondria
  • Mitochondrial Swelling

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Endocrinology

Cite this

González-Hernández, J. C., Aguilera-Aguirre, L., Pérez-Vázquez, V., Ramírez, J., Clemente-Guerrero, M., Cortés-Rojo, C., & Saavedra-Molina, A. (2003). Effect of D-amino acids on some mitochondrial functions in rat liver. Amino Acids, 24(1-2), 163-169.

Effect of D-amino acids on some mitochondrial functions in rat liver. / González-Hernández, J. C.; Aguilera-Aguirre, L.; Pérez-Vázquez, V.; Ramírez, J.; Clemente-Guerrero, M.; Cortés-Rojo, C.; Saavedra-Molina, A.

In: Amino Acids, Vol. 24, No. 1-2, 03.2003, p. 163-169.

Research output: Contribution to journalArticle

González-Hernández, JC, Aguilera-Aguirre, L, Pérez-Vázquez, V, Ramírez, J, Clemente-Guerrero, M, Cortés-Rojo, C & Saavedra-Molina, A 2003, 'Effect of D-amino acids on some mitochondrial functions in rat liver', Amino Acids, vol. 24, no. 1-2, pp. 163-169.
González-Hernández JC, Aguilera-Aguirre L, Pérez-Vázquez V, Ramírez J, Clemente-Guerrero M, Cortés-Rojo C et al. Effect of D-amino acids on some mitochondrial functions in rat liver. Amino Acids. 2003 Mar;24(1-2):163-169.
González-Hernández, J. C. ; Aguilera-Aguirre, L. ; Pérez-Vázquez, V. ; Ramírez, J. ; Clemente-Guerrero, M. ; Cortés-Rojo, C. ; Saavedra-Molina, A. / Effect of D-amino acids on some mitochondrial functions in rat liver. In: Amino Acids. 2003 ; Vol. 24, No. 1-2. pp. 163-169.
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