Effect of D-amino acids on some mitochondrial functions in rat liver

J. C. González-Hernández, L. Aguilera-Aguirre, V. Pérez-Vázquez, J. Ramírez, M. Clemente-Guerrero, C. Cortés-Rojo, A. Saavedra-Molina

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9 Scopus citations

Abstract

We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (ΔΨ) was decreased in the presence of 1 μM Ca2+. The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalAmino Acids
Volume24
Issue number1-2
StatePublished - Mar 1 2003

Keywords

  • D-Amino acids
  • Free radicals
  • Liver
  • Membrane potential
  • Mitochondria
  • Mitochondrial Swelling

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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    González-Hernández, J. C., Aguilera-Aguirre, L., Pérez-Vázquez, V., Ramírez, J., Clemente-Guerrero, M., Cortés-Rojo, C., & Saavedra-Molina, A. (2003). Effect of D-amino acids on some mitochondrial functions in rat liver. Amino Acids, 24(1-2), 163-169.