Effect of D-amino acids on some mitochondrial functions in rat liver

J. C. González-Hernández; L. Aguilera-Aguirre; V. Pérez-Vázquez; J. Ramírez; M. Clemente-Guerrero; C. Cortés-Rojo; A. Saavedra-Molina

doi:10.1007/s00726-002-0317-5

Effect of D-amino acids on some mitochondrial functions in rat liver

J. C. González-Hernández
, L. Aguilera-Aguirre
, V. Pérez-Vázquez
, J. Ramírez
, M. Clemente-Guerrero
, C. Cortés-Rojo
, A. Saavedra-Molina

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (ΔΨ) was decreased in the presence of 1 μM Ca²⁺. The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.

Original language	English (US)
Pages (from-to)	163-169
Number of pages	7
Journal	Amino Acids
Volume	24
Issue number	1-2
DOIs	https://doi.org/10.1007/s00726-002-0317-5
State	Published - Mar 2003
Externally published	Yes

Keywords

D-Amino acids
Free radicals
Liver
Membrane potential
Mitochondria
Mitochondrial Swelling

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Organic Chemistry

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10.1007/s00726-002-0317-5

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title = "Effect of D-amino acids on some mitochondrial functions in rat liver",

abstract = "We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (ΔΨ) was decreased in the presence of 1 μM Ca2+. The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.",

keywords = "D-Amino acids, Free radicals, Liver, Membrane potential, Mitochondria, Mitochondrial Swelling",

author = "Gonz{\'a}lez-Hern{\'a}ndez, \{J. C.\} and L. Aguilera-Aguirre and V. P{\'e}rez-V{\'a}zquez and J. Ram{\'i}rez and M. Clemente-Guerrero and C. Cort{\'e}s-Rojo and A. Saavedra-Molina",

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T1 - Effect of D-amino acids on some mitochondrial functions in rat liver

AU - González-Hernández, J. C.

AU - Aguilera-Aguirre, L.

AU - Pérez-Vázquez, V.

AU - Ramírez, J.

AU - Clemente-Guerrero, M.

AU - Cortés-Rojo, C.

AU - Saavedra-Molina, A.

PY - 2003/3

Y1 - 2003/3

N2 - We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (ΔΨ) was decreased in the presence of 1 μM Ca2+. The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.

AB - We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (ΔΨ) was decreased in the presence of 1 μM Ca2+. The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.

KW - D-Amino acids

KW - Free radicals

KW - Liver

KW - Membrane potential

KW - Mitochondria

KW - Mitochondrial Swelling

UR - https://www.scopus.com/pages/publications/0037355885

UR - https://www.scopus.com/pages/publications/0037355885#tab=citedBy

U2 - 10.1007/s00726-002-0317-5

DO - 10.1007/s00726-002-0317-5

M3 - Article

C2 - 12624749

AN - SCOPUS:0037355885

SN - 0939-4451

VL - 24

SP - 163

EP - 169

JO - Amino Acids

JF - Amino Acids

IS - 1-2

ER -

Effect of D-amino acids on some mitochondrial functions in rat liver

Abstract

Keywords

ASJC Scopus subject areas

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