Effect of delirium and other major complications on outcomes after elective surgery in older adults

Lauren J. Gleason, Eva M. Schmitt, Cyrus M. Kosar, Patricia Tabloski, Jane S. Saczynski, Thomas Robinson, Zara Cooper, Selwyn O. Rogers, Richard N. Jones, Edward R. Marcantonio, Sharon K. Inouye

    Research output: Contribution to journalArticle

    80 Citations (Scopus)

    Abstract

    IMPORTANCE: Major postoperative complications and delirium contribute independently to adverse outcomes and high resource use in patients who undergo major surgery; however, their interrelationship is not well examined. OBJECTIVE: To evaluate the association of major postoperative complications and delirium, alone and combined, with adverse outcomes after surgery. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study in 2 large academic medical centers of 566 patients who were 70 years or older without recognized dementia or a history of delirium and underwent elective major orthopedic, vascular, or abdominal surgical procedures with aminimum 3-day hospitalization between June 18, 2010, and August 8, 2013. Data analysis took place from December 13, 2013, through May 1, 2015. MAIN OUTCOMES AND MEASURES: Major postoperative complications, defined as life-altering or life-threatening events (Accordion Severity grade 2 or higher), were identified by expert-panel adjudication. Delirium was measured daily with the Confusion Assessment Method and avalidated medical record review method. The following 4 subgroups were analyzed: (1) no complications or delirium; (2) complications only; (3) delirium only; and (4) complications and delirium. Adverse outcomes included a length of stay (LOS) of more than 5 days, institutional discharge, and rehospitalization within 30 days of discharge. RESULTS: In the 566 participants, the mean (SD) age was 76.7 (5.2) years, 236 (41.7%) were male, and 523 (92.4%) were white. Forty-seven patients (8.3%) developed major complications and 135 (23.9%) developed delirium. Compared with no complications or delirium as the reference group, major complications only contributed to prolonged LOS only (relative risk [RR], 2.8; 95% CI, 1.9-4.0); by contrast, delirium only significantly increased all adverse outcomes, including prolonged LOS (RR, 1.9; 95% CI, 1.4-2.7), institutional discharge (RR, 1.5; 95% CI, 1.3-1.7), and 30-day readmission (RR, 2.3; 95% CI, 1.4-3.7). The subgroup with complications and delirium had the highest rates of all adverse outcomes, including prolonged LOS (RR, 3.4; 95% CI, 2.3-4.8), institutional discharge (RR, 1.8; 95% CI, 1.4-2.5), and 30-day readmission (RR, 3.0; 95% CI, 1.3-6.8). Delirium exerted the highest attributable risk at the population level (5.8%; 95% CI, 4.7-6.8) compared with all other adverse events (prolonged LOS, institutional discharge, or readmission). CONCLUSIONS AND RELEVANCE: Major postoperative complications and delirium are separately associated with adverse events and demonstrate a combined effect. Delirium occurs more frequently and has a greater effect at the population level than other major complications.

    Original languageEnglish (US)
    Pages (from-to)1134-1140
    Number of pages7
    JournalJAMA Surgery
    Volume150
    Issue number12
    DOIs
    StatePublished - Dec 1 2015

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    Delirium
    Length of Stay
    Confusion
    Medical Records
    Orthopedics
    Blood Vessels
    Dementia

    ASJC Scopus subject areas

    • Surgery

    Cite this

    Gleason, L. J., Schmitt, E. M., Kosar, C. M., Tabloski, P., Saczynski, J. S., Robinson, T., ... Inouye, S. K. (2015). Effect of delirium and other major complications on outcomes after elective surgery in older adults. JAMA Surgery, 150(12), 1134-1140. https://doi.org/10.1001/jamasurg.2015.2606

    Effect of delirium and other major complications on outcomes after elective surgery in older adults. / Gleason, Lauren J.; Schmitt, Eva M.; Kosar, Cyrus M.; Tabloski, Patricia; Saczynski, Jane S.; Robinson, Thomas; Cooper, Zara; Rogers, Selwyn O.; Jones, Richard N.; Marcantonio, Edward R.; Inouye, Sharon K.

    In: JAMA Surgery, Vol. 150, No. 12, 01.12.2015, p. 1134-1140.

    Research output: Contribution to journalArticle

    Gleason, LJ, Schmitt, EM, Kosar, CM, Tabloski, P, Saczynski, JS, Robinson, T, Cooper, Z, Rogers, SO, Jones, RN, Marcantonio, ER & Inouye, SK 2015, 'Effect of delirium and other major complications on outcomes after elective surgery in older adults', JAMA Surgery, vol. 150, no. 12, pp. 1134-1140. https://doi.org/10.1001/jamasurg.2015.2606
    Gleason LJ, Schmitt EM, Kosar CM, Tabloski P, Saczynski JS, Robinson T et al. Effect of delirium and other major complications on outcomes after elective surgery in older adults. JAMA Surgery. 2015 Dec 1;150(12):1134-1140. https://doi.org/10.1001/jamasurg.2015.2606
    Gleason, Lauren J. ; Schmitt, Eva M. ; Kosar, Cyrus M. ; Tabloski, Patricia ; Saczynski, Jane S. ; Robinson, Thomas ; Cooper, Zara ; Rogers, Selwyn O. ; Jones, Richard N. ; Marcantonio, Edward R. ; Inouye, Sharon K. / Effect of delirium and other major complications on outcomes after elective surgery in older adults. In: JAMA Surgery. 2015 ; Vol. 150, No. 12. pp. 1134-1140.
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    abstract = "IMPORTANCE: Major postoperative complications and delirium contribute independently to adverse outcomes and high resource use in patients who undergo major surgery; however, their interrelationship is not well examined. OBJECTIVE: To evaluate the association of major postoperative complications and delirium, alone and combined, with adverse outcomes after surgery. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study in 2 large academic medical centers of 566 patients who were 70 years or older without recognized dementia or a history of delirium and underwent elective major orthopedic, vascular, or abdominal surgical procedures with aminimum 3-day hospitalization between June 18, 2010, and August 8, 2013. Data analysis took place from December 13, 2013, through May 1, 2015. MAIN OUTCOMES AND MEASURES: Major postoperative complications, defined as life-altering or life-threatening events (Accordion Severity grade 2 or higher), were identified by expert-panel adjudication. Delirium was measured daily with the Confusion Assessment Method and avalidated medical record review method. The following 4 subgroups were analyzed: (1) no complications or delirium; (2) complications only; (3) delirium only; and (4) complications and delirium. Adverse outcomes included a length of stay (LOS) of more than 5 days, institutional discharge, and rehospitalization within 30 days of discharge. RESULTS: In the 566 participants, the mean (SD) age was 76.7 (5.2) years, 236 (41.7{\%}) were male, and 523 (92.4{\%}) were white. Forty-seven patients (8.3{\%}) developed major complications and 135 (23.9{\%}) developed delirium. Compared with no complications or delirium as the reference group, major complications only contributed to prolonged LOS only (relative risk [RR], 2.8; 95{\%} CI, 1.9-4.0); by contrast, delirium only significantly increased all adverse outcomes, including prolonged LOS (RR, 1.9; 95{\%} CI, 1.4-2.7), institutional discharge (RR, 1.5; 95{\%} CI, 1.3-1.7), and 30-day readmission (RR, 2.3; 95{\%} CI, 1.4-3.7). The subgroup with complications and delirium had the highest rates of all adverse outcomes, including prolonged LOS (RR, 3.4; 95{\%} CI, 2.3-4.8), institutional discharge (RR, 1.8; 95{\%} CI, 1.4-2.5), and 30-day readmission (RR, 3.0; 95{\%} CI, 1.3-6.8). Delirium exerted the highest attributable risk at the population level (5.8{\%}; 95{\%} CI, 4.7-6.8) compared with all other adverse events (prolonged LOS, institutional discharge, or readmission). CONCLUSIONS AND RELEVANCE: Major postoperative complications and delirium are separately associated with adverse events and demonstrate a combined effect. Delirium occurs more frequently and has a greater effect at the population level than other major complications.",
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    T1 - Effect of delirium and other major complications on outcomes after elective surgery in older adults

    AU - Gleason, Lauren J.

    AU - Schmitt, Eva M.

    AU - Kosar, Cyrus M.

    AU - Tabloski, Patricia

    AU - Saczynski, Jane S.

    AU - Robinson, Thomas

    AU - Cooper, Zara

    AU - Rogers, Selwyn O.

    AU - Jones, Richard N.

    AU - Marcantonio, Edward R.

    AU - Inouye, Sharon K.

    PY - 2015/12/1

    Y1 - 2015/12/1

    N2 - IMPORTANCE: Major postoperative complications and delirium contribute independently to adverse outcomes and high resource use in patients who undergo major surgery; however, their interrelationship is not well examined. OBJECTIVE: To evaluate the association of major postoperative complications and delirium, alone and combined, with adverse outcomes after surgery. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study in 2 large academic medical centers of 566 patients who were 70 years or older without recognized dementia or a history of delirium and underwent elective major orthopedic, vascular, or abdominal surgical procedures with aminimum 3-day hospitalization between June 18, 2010, and August 8, 2013. Data analysis took place from December 13, 2013, through May 1, 2015. MAIN OUTCOMES AND MEASURES: Major postoperative complications, defined as life-altering or life-threatening events (Accordion Severity grade 2 or higher), were identified by expert-panel adjudication. Delirium was measured daily with the Confusion Assessment Method and avalidated medical record review method. The following 4 subgroups were analyzed: (1) no complications or delirium; (2) complications only; (3) delirium only; and (4) complications and delirium. Adverse outcomes included a length of stay (LOS) of more than 5 days, institutional discharge, and rehospitalization within 30 days of discharge. RESULTS: In the 566 participants, the mean (SD) age was 76.7 (5.2) years, 236 (41.7%) were male, and 523 (92.4%) were white. Forty-seven patients (8.3%) developed major complications and 135 (23.9%) developed delirium. Compared with no complications or delirium as the reference group, major complications only contributed to prolonged LOS only (relative risk [RR], 2.8; 95% CI, 1.9-4.0); by contrast, delirium only significantly increased all adverse outcomes, including prolonged LOS (RR, 1.9; 95% CI, 1.4-2.7), institutional discharge (RR, 1.5; 95% CI, 1.3-1.7), and 30-day readmission (RR, 2.3; 95% CI, 1.4-3.7). The subgroup with complications and delirium had the highest rates of all adverse outcomes, including prolonged LOS (RR, 3.4; 95% CI, 2.3-4.8), institutional discharge (RR, 1.8; 95% CI, 1.4-2.5), and 30-day readmission (RR, 3.0; 95% CI, 1.3-6.8). Delirium exerted the highest attributable risk at the population level (5.8%; 95% CI, 4.7-6.8) compared with all other adverse events (prolonged LOS, institutional discharge, or readmission). CONCLUSIONS AND RELEVANCE: Major postoperative complications and delirium are separately associated with adverse events and demonstrate a combined effect. Delirium occurs more frequently and has a greater effect at the population level than other major complications.

    AB - IMPORTANCE: Major postoperative complications and delirium contribute independently to adverse outcomes and high resource use in patients who undergo major surgery; however, their interrelationship is not well examined. OBJECTIVE: To evaluate the association of major postoperative complications and delirium, alone and combined, with adverse outcomes after surgery. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study in 2 large academic medical centers of 566 patients who were 70 years or older without recognized dementia or a history of delirium and underwent elective major orthopedic, vascular, or abdominal surgical procedures with aminimum 3-day hospitalization between June 18, 2010, and August 8, 2013. Data analysis took place from December 13, 2013, through May 1, 2015. MAIN OUTCOMES AND MEASURES: Major postoperative complications, defined as life-altering or life-threatening events (Accordion Severity grade 2 or higher), were identified by expert-panel adjudication. Delirium was measured daily with the Confusion Assessment Method and avalidated medical record review method. The following 4 subgroups were analyzed: (1) no complications or delirium; (2) complications only; (3) delirium only; and (4) complications and delirium. Adverse outcomes included a length of stay (LOS) of more than 5 days, institutional discharge, and rehospitalization within 30 days of discharge. RESULTS: In the 566 participants, the mean (SD) age was 76.7 (5.2) years, 236 (41.7%) were male, and 523 (92.4%) were white. Forty-seven patients (8.3%) developed major complications and 135 (23.9%) developed delirium. Compared with no complications or delirium as the reference group, major complications only contributed to prolonged LOS only (relative risk [RR], 2.8; 95% CI, 1.9-4.0); by contrast, delirium only significantly increased all adverse outcomes, including prolonged LOS (RR, 1.9; 95% CI, 1.4-2.7), institutional discharge (RR, 1.5; 95% CI, 1.3-1.7), and 30-day readmission (RR, 2.3; 95% CI, 1.4-3.7). The subgroup with complications and delirium had the highest rates of all adverse outcomes, including prolonged LOS (RR, 3.4; 95% CI, 2.3-4.8), institutional discharge (RR, 1.8; 95% CI, 1.4-2.5), and 30-day readmission (RR, 3.0; 95% CI, 1.3-6.8). Delirium exerted the highest attributable risk at the population level (5.8%; 95% CI, 4.7-6.8) compared with all other adverse events (prolonged LOS, institutional discharge, or readmission). CONCLUSIONS AND RELEVANCE: Major postoperative complications and delirium are separately associated with adverse events and demonstrate a combined effect. Delirium occurs more frequently and has a greater effect at the population level than other major complications.

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