Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

S. Ayachi; C. E. Hall; O. B. Holland; C. Gomez-Sanchez

doi:10.3181/00379727-152-39364

Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

S. Ayachi, C. E. Hall, O. B. Holland, C. Gomez-Sanchez

Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Intact female Sprague–Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16β-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16β-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.

Original language	English (US)
Pages (from-to)	218-220
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	152
Issue number	2
DOIs	https://doi.org/10.3181/00379727-152-39364
State	Published - Jun 1976

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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AU - Gomez-Sanchez, C.

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Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

Abstract

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