Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

S. Ayachi; C. E. Hall; O. B. Holland; C. Gomez-Sanchez

doi:10.3181/00379727-152-39364

Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

S. Ayachi, C. E. Hall, O. B. Holland, C. Gomez-Sanchez

Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Intact female Sprague–Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16β-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16β-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.

Original language	English (US)
Pages (from-to)	218-220
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	152
Issue number	2
DOIs	https://doi.org/10.3181/00379727-152-39364
State	Published - Jun 1976

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.3181/00379727-152-39364

Cite this

@article{2a1e8e24aaef44d79d90ee58e0b23f91,

title = "Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats",

abstract = "Intact female Sprague–Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16β-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16β-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.",

author = "S. Ayachi and Hall, {C. E.} and Holland, {O. B.} and C. Gomez-Sanchez",

year = "1976",

month = jun,

doi = "10.3181/00379727-152-39364",

language = "English (US)",

volume = "152",

pages = "218--220",

journal = "Proceedings of the Society for Experimental Biology and Medicine",

issn = "0037-9727",

publisher = "SAGE Publications Ltd",

number = "2",

}

TY - JOUR

T1 - Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

AU - Ayachi, S.

AU - Hall, C. E.

AU - Holland, O. B.

AU - Gomez-Sanchez, C.

PY - 1976/6

Y1 - 1976/6

N2 - Intact female Sprague–Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16β-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16β-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.

AB - Intact female Sprague–Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16β-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16β-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.

UR - http://www.scopus.com/inward/record.url?scp=0017159457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017159457&partnerID=8YFLogxK

U2 - 10.3181/00379727-152-39364

DO - 10.3181/00379727-152-39364

M3 - Article

C2 - 132667

AN - SCOPUS:0017159457

SN - 0037-9727

VL - 152

SP - 218

EP - 220

JO - Proceedings of the Society for Experimental Biology and Medicine

JF - Proceedings of the Society for Experimental Biology and Medicine

IS - 2

ER -

Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this