Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

S. Ayachi, C. E. Hall, O. B. Holland, C. Gomez-Sanchez

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Intact female Sprague–Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16β-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16β-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.

Original languageEnglish (US)
Pages (from-to)218-220
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume152
Issue number2
DOIs
StatePublished - Jun 1976

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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