Intact female Sprague–Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16β-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16β-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.
|Original language||English (US)|
|Number of pages||3|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jun 1976|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)