Abstract
Intact female Sprague–Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16β-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16β-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 218-220 |
| Number of pages | 3 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 152 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1976 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Ayachi, S., Hall, C. E., Holland, O. B., & Gomez-Sanchez, C. (1976). Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats. Proceedings of the Society for Experimental Biology and Medicine, 152(2), 218-220. https://doi.org/10.3181/00379727-152-39364