Abstract
Intact female Sprague–Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16β-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16β-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 218-220 |
| Number of pages | 3 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 152 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1976 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology