Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

S. Ayachi; C. E. Hall; O. B. Holland; C. Gomez-Sanchez

doi:10.3181/00379727-152-39364

Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

S. Ayachi
, C. E. Hall
, O. B. Holland
, C. Gomez-Sanchez

Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Intact female Sprague–Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16β-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16β-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.

Original language	English (US)
Pages (from-to)	218-220
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
Volume	152
Issue number	2
DOIs	https://doi.org/10.3181/00379727-152-39364
State	Published - Jun 1976

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3181/00379727-152-39364

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Ayachi, S., Hall, C. E., Holland, O. B., & Gomez-Sanchez, C. (1976). Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.), 152(2), 218-220. https://doi.org/10.3181/00379727-152-39364

Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats. / Ayachi, S.; Hall, C. E.; Holland, O. B. et al.
In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.), Vol. 152, No. 2, 06.1976, p. 218-220.

Research output: Contribution to journal › Article › peer-review

Ayachi, S, Hall, CE, Holland, OB & Gomez-Sanchez, C 1976, 'Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats', Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.), vol. 152, no. 2, pp. 218-220. https://doi.org/10.3181/00379727-152-39364

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Effect of Deoxycorticosterone Acetate and 16β-Hydroxy-Dehydroepiandrosterone on Blood Pressure and Plasma Renin Activity of Rats

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