Effect of dextran-70 on increased microvascular fluid and protein flux after thermal injury

George Kramer, R. A. Gunther, M. L. Nerlich, S. S. Zweifach, R. H. Demling

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The effect of a colloid (dextran-70) infusion on increased microvascular fluid and protein flux after thermal injury was compared with that seen with a crystalloid infusion. Lymph flow (Q̇(L)) and lymph/plasma (L/P) protein content were used to monitor microvascular fluid flux and protein permeability in the lung and in burned and nonburned soft tissue, namely, skin and subcutaneous tissue, for 72 h in 13 sheep given a 30% TBS full-thickness burn. Vascular pressures were maintained constant with dextran in saline or lactate Ringer's. Mean fluid requirements for dextran were one-half that for crystalloid during the 24-h resuscitation period. However, plasma proteins decreased by 50% with dextran compared to 30% with crystalloid. An increase of 2-2.5 fold in Q̇(L) was seen during resuscitation in the lung and nonburned soft tissue with crystalloid while the L/P protein ratio decreased, indicating no change in protein permeability. This Q̇(L) response was prevented during dextran infusion. A rebound increase in soft tissue Q̇(L) occurred after discontinuation of dextran, probably as a result of the severe residual hypoproteinemia. Burn Q̇(L) and L/P were markedly increased during the entire 72-h period, indicating increased permeability. Dextran infusion accentuated the Q̇(L) response in the burn microcirculation. We conclude that dextran decreases edema in nonburned tissue, but appears to increase the protein loss from burn tissue.

Original languageEnglish (US)
Pages (from-to)529-541
Number of pages13
JournalCirculatory Shock
Volume9
Issue number5
StatePublished - 1982
Externally publishedYes

Fingerprint

Dextrans
Hot Temperature
Lymph
Wounds and Injuries
Proteins
Blood Proteins
Permeability
Resuscitation
dextran - saline drug combination
Hypoproteinemia
Lung
Subcutaneous Tissue
Colloids
Microcirculation
Blood Vessels
Edema
Sheep
Pressure
Skin
crystalloid solutions

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kramer, G., Gunther, R. A., Nerlich, M. L., Zweifach, S. S., & Demling, R. H. (1982). Effect of dextran-70 on increased microvascular fluid and protein flux after thermal injury. Circulatory Shock, 9(5), 529-541.

Effect of dextran-70 on increased microvascular fluid and protein flux after thermal injury. / Kramer, George; Gunther, R. A.; Nerlich, M. L.; Zweifach, S. S.; Demling, R. H.

In: Circulatory Shock, Vol. 9, No. 5, 1982, p. 529-541.

Research output: Contribution to journalArticle

Kramer, G, Gunther, RA, Nerlich, ML, Zweifach, SS & Demling, RH 1982, 'Effect of dextran-70 on increased microvascular fluid and protein flux after thermal injury', Circulatory Shock, vol. 9, no. 5, pp. 529-541.
Kramer, George ; Gunther, R. A. ; Nerlich, M. L. ; Zweifach, S. S. ; Demling, R. H. / Effect of dextran-70 on increased microvascular fluid and protein flux after thermal injury. In: Circulatory Shock. 1982 ; Vol. 9, No. 5. pp. 529-541.
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