Effect of dietary protein on striatal dopamine formation following L-dopa administration: An in vivo study

T. Brannan, J. Martinez-Tica, M. D. Yahr

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We varied the diet of rats and monitored extracellular levels of dopamine in the striatum. Following L-dopa administration, the increase in striatal dopamine levels was attenuated by 78% in rats that had consumed a high protein diet as opposed to a low protein diet. Similarly, the increase in striatal dopamine levels was attenuated by 61% in rats that had just eaten a protein-containing meal as compared to fasting animals. These findings demonstrate that dietary protein strongly affects brain dopamine formation from exogenous L-dopa.

Original languageEnglish (US)
Pages (from-to)1125-1127
Number of pages3
JournalNeuropharmacology
Volume30
Issue number10
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Corpus Striatum
Dietary Proteins
Levodopa
Dopamine
Diet
Protein-Restricted Diet
Meals
Fasting
Proteins
Brain

Keywords

  • cerebral microdialysis
  • diet
  • dopamine
  • L-dopa
  • Parkinson's disease
  • protein

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Effect of dietary protein on striatal dopamine formation following L-dopa administration : An in vivo study. / Brannan, T.; Martinez-Tica, J.; Yahr, M. D.

In: Neuropharmacology, Vol. 30, No. 10, 1991, p. 1125-1127.

Research output: Contribution to journalArticle

Brannan, T. ; Martinez-Tica, J. ; Yahr, M. D. / Effect of dietary protein on striatal dopamine formation following L-dopa administration : An in vivo study. In: Neuropharmacology. 1991 ; Vol. 30, No. 10. pp. 1125-1127.
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