Effect of dietary protein on striatal dopamine formation following L-dopa administration: An in vivo study

T. Brannan, J. Martinez-Tica, M. D. Yahr

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We varied the diet of rats and monitored extracellular levels of dopamine in the striatum. Following L-dopa administration, the increase in striatal dopamine levels was attenuated by 78% in rats that had consumed a high protein diet as opposed to a low protein diet. Similarly, the increase in striatal dopamine levels was attenuated by 61% in rats that had just eaten a protein-containing meal as compared to fasting animals. These findings demonstrate that dietary protein strongly affects brain dopamine formation from exogenous L-dopa.

Original languageEnglish (US)
Pages (from-to)1125-1127
Number of pages3
JournalNeuropharmacology
Volume30
Issue number10
DOIs
StatePublished - Oct 1991

Keywords

  • L-dopa
  • Parkinson's disease
  • cerebral microdialysis
  • diet
  • dopamine
  • protein

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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