Effect of growth hormone replacement therapy on cognition after traumatic brain injury

Walter M. High, Maria Briones-Galang, Jessica A. Clark, Charles Gilkison, Kurt A. Mossberg, Dennis J. Zgaljardic, Brent E. Masel, Randall Urban

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) is a major public health issue, and yet medical science has little to offer for the persistent symptoms that prevent many of these individuals from fully re-entering society. Post-traumatic hypopituitarism, and specifically growth hormone deficiency (GHD), has been found in a large percentage of individuals with chronic moderate to severe TBI. Presently, there are no published treatment studies of hormone replacement in this population. In this study, 83 subjects with chronic TBI were screened for hypopituitarism. Forty-two subjects were found to have either GHD or GH insufficiency (GHI), of which 23 agreed to be randomized to either a year of GH replacement or placebo. All subjects completed the study with no untoward side effects from treatment. A battery of neuropsychological tests and functional measures were administered before and after treatment. Improvement was seen on the following tests: Dominant Hand Finger Tapping Test, Wechsler Adult Intelligence Scale III-Information Processing Speed Index, California Verbal Learning Test II, and the Wisconsin Card Sorting Test (executive functioning). The findings of this pilot study provide preliminary evidence suggesting that some of the cognitive impairments observed in persons who are GHD/GHI after TBI may be partially reversible with appropriate GH replacement therapy.

Original languageEnglish (US)
Pages (from-to)1565-1575
Number of pages11
JournalJournal of Neurotrauma
Volume27
Issue number9
DOIs
StatePublished - Sep 1 2010

Fingerprint

Hormone Replacement Therapy
Cognition
Growth Hormone
Hypopituitarism
Chronic Brain Injury
Verbal Learning
Neuropsychological Tests
Population Dynamics
Therapeutics
Intelligence
Automatic Data Processing
Fingers
Hand
Public Health
Placebos
Hormones
Traumatic Brain Injury

Keywords

  • growth hormone deficiency
  • hypopituitarism
  • traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

High, W. M., Briones-Galang, M., Clark, J. A., Gilkison, C., Mossberg, K. A., Zgaljardic, D. J., ... Urban, R. (2010). Effect of growth hormone replacement therapy on cognition after traumatic brain injury. Journal of Neurotrauma, 27(9), 1565-1575. https://doi.org/10.1089/neu.2009.1253

Effect of growth hormone replacement therapy on cognition after traumatic brain injury. / High, Walter M.; Briones-Galang, Maria; Clark, Jessica A.; Gilkison, Charles; Mossberg, Kurt A.; Zgaljardic, Dennis J.; Masel, Brent E.; Urban, Randall.

In: Journal of Neurotrauma, Vol. 27, No. 9, 01.09.2010, p. 1565-1575.

Research output: Contribution to journalArticle

High, WM, Briones-Galang, M, Clark, JA, Gilkison, C, Mossberg, KA, Zgaljardic, DJ, Masel, BE & Urban, R 2010, 'Effect of growth hormone replacement therapy on cognition after traumatic brain injury', Journal of Neurotrauma, vol. 27, no. 9, pp. 1565-1575. https://doi.org/10.1089/neu.2009.1253
High WM, Briones-Galang M, Clark JA, Gilkison C, Mossberg KA, Zgaljardic DJ et al. Effect of growth hormone replacement therapy on cognition after traumatic brain injury. Journal of Neurotrauma. 2010 Sep 1;27(9):1565-1575. https://doi.org/10.1089/neu.2009.1253
High, Walter M. ; Briones-Galang, Maria ; Clark, Jessica A. ; Gilkison, Charles ; Mossberg, Kurt A. ; Zgaljardic, Dennis J. ; Masel, Brent E. ; Urban, Randall. / Effect of growth hormone replacement therapy on cognition after traumatic brain injury. In: Journal of Neurotrauma. 2010 ; Vol. 27, No. 9. pp. 1565-1575.
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