Effect of Helicobacter pylori on gastric epithelial cells

Shatha Alzahrani, Taslima T. Lina, Jazmin Gonzalez, Irina V. Pinchuk, Ellen J. Beswick, Victor E. Reyes

Research output: Contribution to journalArticlepeer-review

123 Scopus citations


The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori (H. pylori ) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori 's avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori.

Original languageEnglish (US)
Pages (from-to)12767-12780
Number of pages14
JournalWorld journal of gastroenterology
Issue number36
StatePublished - Sep 28 2014


  • Apoptosis
  • Chronic inflammation
  • Gastric cancer
  • Gastric diseases
  • Gastric epithelial cells
  • Helicobacter pylori
  • Proinflammatory cytokines

ASJC Scopus subject areas

  • Gastroenterology


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