Effect of Helicobacter pylori on gastric epithelial cells

Shatha Alzahrani, Taslima T. Lina, Jazmin Gonzalez, Iryna Pinchuk, Ellen J. Beswick, Victor Reyes

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori (H. pylori ) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori 's avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori.

Original languageEnglish (US)
Pages (from-to)12767-12780
Number of pages14
JournalWorld Journal of Gastroenterology
Volume20
Issue number36
DOIs
StatePublished - Sep 28 2014

Fingerprint

Helicobacter pylori
Stomach
Epithelial Cells
Epithelium
Infection
Innate Immunity
Inflammation
Mucosal Immunity
Autophagy
Cell Surface Receptors
Virulence Factors
Gram-Negative Bacteria
DNA Damage
Apoptosis
Cytokines
Population
Neoplasms

Keywords

  • Apoptosis
  • Chronic inflammation
  • Gastric cancer
  • Gastric diseases
  • Gastric epithelial cells
  • Helicobacter pylori
  • Proinflammatory cytokines

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Alzahrani, S., Lina, T. T., Gonzalez, J., Pinchuk, I., Beswick, E. J., & Reyes, V. (2014). Effect of Helicobacter pylori on gastric epithelial cells. World Journal of Gastroenterology, 20(36), 12767-12780. https://doi.org/10.3748/wjg.v20.i36.12767

Effect of Helicobacter pylori on gastric epithelial cells. / Alzahrani, Shatha; Lina, Taslima T.; Gonzalez, Jazmin; Pinchuk, Iryna; Beswick, Ellen J.; Reyes, Victor.

In: World Journal of Gastroenterology, Vol. 20, No. 36, 28.09.2014, p. 12767-12780.

Research output: Contribution to journalArticle

Alzahrani, S, Lina, TT, Gonzalez, J, Pinchuk, I, Beswick, EJ & Reyes, V 2014, 'Effect of Helicobacter pylori on gastric epithelial cells', World Journal of Gastroenterology, vol. 20, no. 36, pp. 12767-12780. https://doi.org/10.3748/wjg.v20.i36.12767
Alzahrani, Shatha ; Lina, Taslima T. ; Gonzalez, Jazmin ; Pinchuk, Iryna ; Beswick, Ellen J. ; Reyes, Victor. / Effect of Helicobacter pylori on gastric epithelial cells. In: World Journal of Gastroenterology. 2014 ; Vol. 20, No. 36. pp. 12767-12780.
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