Effect of hemodilution on tissue perfusion and blood coagulation during radical hysterectomy

Joseph T. Santoso, Edward V. Hannigan, Lyuba Levine, Daneshvari R. Solanki, Mali Mathru

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective. The goal of this study was to evaluate the safety of hemodilution on global and splanchnic perfusion and blood coagulation during radical hysterectomy. Methods. A pulmonary artery catheter and a gastric tonometry catheter were placed in 16 patients with cervical carcinoma. Global perfusion indices, splanchnic perfusion index, and coagulation tests were obtained. Blood was removed to achieve a hemoglobin measurement of 8-9 9 g/dL. Three more measurements were repeated after hemodilution, at the end of surgery, and after the retransfusion of blood. Analysis of variance was used to determine statistical significance. Results. Sixteen patients with cervical carcinoma had 1.0 ± 0.3 L (mean ± SD) of blood removed and had a blood loss of 0.8 ± 0.7 L. Hemodiluted preoperative hemoglobin was 8.7 ± 1 g/dL. All of the global perfusion indices, except for arterial pH and oxygen consumption, decreased after hemodilution and recovered with the retransfusion of blood (P ≤ 0.004). Splanchnic perfusion and coagulation tests were unchanged (P ≥ 0.1). Major complication was pulmonary edema in one patient. Conclusion. Hemodilution during radical hysterectomy, in this select group of patients, does not appear to compromise tissue perfusion or coagulation.

Original languageEnglish (US)
Pages (from-to)252-256
Number of pages5
JournalGynecologic Oncology
Volume82
Issue number2
DOIs
StatePublished - 2001

Fingerprint

Hemodilution
Blood Coagulation
Hysterectomy
Perfusion
Viscera
Hemoglobins
Catheters
Carcinoma
Manometry
Pulmonary Edema
Oxygen Consumption
Pulmonary Artery
Stomach
Analysis of Variance
Safety

Keywords

  • Anemia
  • Coagulation
  • Hemodilution
  • Radical hysterectomy
  • Tissue perfusion

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Santoso, J. T., Hannigan, E. V., Levine, L., Solanki, D. R., & Mathru, M. (2001). Effect of hemodilution on tissue perfusion and blood coagulation during radical hysterectomy. Gynecologic Oncology, 82(2), 252-256. https://doi.org/10.1006/gyno.2001.6302

Effect of hemodilution on tissue perfusion and blood coagulation during radical hysterectomy. / Santoso, Joseph T.; Hannigan, Edward V.; Levine, Lyuba; Solanki, Daneshvari R.; Mathru, Mali.

In: Gynecologic Oncology, Vol. 82, No. 2, 2001, p. 252-256.

Research output: Contribution to journalArticle

Santoso, JT, Hannigan, EV, Levine, L, Solanki, DR & Mathru, M 2001, 'Effect of hemodilution on tissue perfusion and blood coagulation during radical hysterectomy', Gynecologic Oncology, vol. 82, no. 2, pp. 252-256. https://doi.org/10.1006/gyno.2001.6302
Santoso, Joseph T. ; Hannigan, Edward V. ; Levine, Lyuba ; Solanki, Daneshvari R. ; Mathru, Mali. / Effect of hemodilution on tissue perfusion and blood coagulation during radical hysterectomy. In: Gynecologic Oncology. 2001 ; Vol. 82, No. 2. pp. 252-256.
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