Effect of hemorrhage rate on early hemodynamic responses in conscious sheep

Christopher G. Scully, Chathuri Daluwatte, Nicole R. Marques, Muzna Khan, Michael Salter, Jordan Wolf, Christina Nelson, John Salsbury, Perenlei Enkhbaatar, Michael Kinsky, George Kramer, David G. Strauss

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Physiological compensatory mechanisms can mask the extent of hemorrhage in conscious mammals, which can be further complicated by individual tolerance and variations in hemorrhage onset and duration. We assessed the effect of hemorrhage rate on tolerance and early physiologic responses to hemorrhage in conscious sheep. Eight Merino ewes (37.4±1.1 kg) were subjected to fast (1.25 mL/kg/min) and slow (0.25 mL/kg/min) hemorrhages separated by at least 3days. Blood was withdrawn until a drop in mean arterial pressure (MAP) of >30mmHg and returned at the end of the experiment. Continuous monitoring included MAP, central venous pressure, pulmonary artery pressure, pulse oximetry, and tissue oximetry. Cardiac output by thermodilution and arterial blood samples were also measured. The effects of fast versus slow hemorrhage rates were compared for total volume of blood removed and stoppage time (when MAP

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalPhysiological Reports
Volume4
Issue number7
DOIs
StatePublished - Apr 1 2016

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Keywords

  • Hemodynamic compensation
  • Hemorrhage
  • Hypovolemia

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology

Cite this

Scully, C. G., Daluwatte, C., Marques, N. R., Khan, M., Salter, M., Wolf, J., Nelson, C., Salsbury, J., Enkhbaatar, P., Kinsky, M., Kramer, G., & Strauss, D. G. (2016). Effect of hemorrhage rate on early hemodynamic responses in conscious sheep. Physiological Reports, 4(7), 1-15. https://doi.org/10.14814/phy2.12739