Effect of hemorrhage rate on early hemodynamic responses in conscious sheep

Christopher G. Scully, Chathuri Daluwatte, Nicole R. Marques, Muzna Khan, Michael Salter, Jordan Wolf, Christina Nelson, John Salsbury, Perenlei Enkhbaatar, Michael Kinsky, George Kramer, David G. Strauss

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Physiological compensatory mechanisms can mask the extent of hemorrhage in conscious mammals, which can be further complicated by individual tolerance and variations in hemorrhage onset and duration. We assessed the effect of hemorrhage rate on tolerance and early physiologic responses to hemorrhage in conscious sheep. Eight Merino ewes (37.4±1.1 kg) were subjected to fast (1.25 mL/kg/min) and slow (0.25 mL/kg/min) hemorrhages separated by at least 3days. Blood was withdrawn until a drop in mean arterial pressure (MAP) of >30mmHg and returned at the end of the experiment. Continuous monitoring included MAP, central venous pressure, pulmonary artery pressure, pulse oximetry, and tissue oximetry. Cardiac output by thermodilution and arterial blood samples were also measured. The effects of fast versus slow hemorrhage rates were compared for total volume of blood removed and stoppage time (when MAP

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalPhysiological Reports
Volume4
Issue number7
DOIs
StatePublished - Apr 1 2016

Fingerprint

Sheep
Hemodynamics
Hemorrhage
Arterial Pressure
Oximetry
Thermodilution
Central Venous Pressure
Masks
Blood Volume
Cardiac Output
Pulmonary Artery
Mammals
Pressure

Keywords

  • Hemodynamic compensation
  • Hemorrhage
  • Hypovolemia

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology

Cite this

Scully, C. G., Daluwatte, C., Marques, N. R., Khan, M., Salter, M., Wolf, J., ... Strauss, D. G. (2016). Effect of hemorrhage rate on early hemodynamic responses in conscious sheep. Physiological Reports, 4(7), 1-15. https://doi.org/10.14814/phy2.12739

Effect of hemorrhage rate on early hemodynamic responses in conscious sheep. / Scully, Christopher G.; Daluwatte, Chathuri; Marques, Nicole R.; Khan, Muzna; Salter, Michael; Wolf, Jordan; Nelson, Christina; Salsbury, John; Enkhbaatar, Perenlei; Kinsky, Michael; Kramer, George; Strauss, David G.

In: Physiological Reports, Vol. 4, No. 7, 01.04.2016, p. 1-15.

Research output: Contribution to journalArticle

Scully, CG, Daluwatte, C, Marques, NR, Khan, M, Salter, M, Wolf, J, Nelson, C, Salsbury, J, Enkhbaatar, P, Kinsky, M, Kramer, G & Strauss, DG 2016, 'Effect of hemorrhage rate on early hemodynamic responses in conscious sheep', Physiological Reports, vol. 4, no. 7, pp. 1-15. https://doi.org/10.14814/phy2.12739
Scully CG, Daluwatte C, Marques NR, Khan M, Salter M, Wolf J et al. Effect of hemorrhage rate on early hemodynamic responses in conscious sheep. Physiological Reports. 2016 Apr 1;4(7):1-15. https://doi.org/10.14814/phy2.12739
Scully, Christopher G. ; Daluwatte, Chathuri ; Marques, Nicole R. ; Khan, Muzna ; Salter, Michael ; Wolf, Jordan ; Nelson, Christina ; Salsbury, John ; Enkhbaatar, Perenlei ; Kinsky, Michael ; Kramer, George ; Strauss, David G. / Effect of hemorrhage rate on early hemodynamic responses in conscious sheep. In: Physiological Reports. 2016 ; Vol. 4, No. 7. pp. 1-15.
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