Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women

Egle Bytautiene; Yuri P. Vedernikov; George R. Saade; Roberto Romero; Robert E. Garfield

doi:10.1067/mob.2003.162

Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women

Egle Bytautiene, Yuri P. Vedernikov, George R. Saade, Roberto Romero, Robert E. Garfield

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

OBJECTIVE: To enhance our understanding of the uterotonic effect of histamine, we compared the effects of histamine on spontaneous phasic and tonic contractile activity of uterine strips from term pregnant nonlaboring women. STUDY DESIGN: Longitudinal uterine strips were used from the lower uterine segment of term pregnant nonlaboring women undergoing elective cesarean section. The concentration-response relationship to histamine (10^-8 to 10^-4 mol/L) was determined in spontaneously contracting strips or in strips contracted tonically with a protein kinase C activator (-)-indolactam V in the presence of H₁ receptor antagonist (S[+]-chlorpheniramine maleate), H₂ receptor antagonist (cimetidine), or solvent. RESULTS: Histamine increased spontaneous phasic myometrial contractions in a concentration-dependent manner. H₁, but not H₂, receptor antagonist significantly attenuated the response to histamine. Histamine significantly reduced tonic contractions of uterine strips induced by indolactam V. H₁ histamine receptor antagonist abolished relaxation, whereas H₂ histamine receptor antagonist had no effect. CONCLUSION: Histamine increases spontaneous, but inhibits tonic, contractions of uterine strips from term pregnant nonlaboring women. Both effects are mediated through activation of H₁ receptors.

Original language	English (US)
Pages (from-to)	774-778
Number of pages	5
Journal	American journal of obstetrics and gynecology
Volume	188
Issue number	3
DOIs	https://doi.org/10.1067/mob.2003.162
State	Published - Mar 1 2003
Externally published	Yes

Keywords

Contractility
Histamine
Histamine receptors
Human myometrium
Pregnancy

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1067/mob.2003.162

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title = "Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women",

abstract = "OBJECTIVE: To enhance our understanding of the uterotonic effect of histamine, we compared the effects of histamine on spontaneous phasic and tonic contractile activity of uterine strips from term pregnant nonlaboring women. STUDY DESIGN: Longitudinal uterine strips were used from the lower uterine segment of term pregnant nonlaboring women undergoing elective cesarean section. The concentration-response relationship to histamine (10-8 to 10-4 mol/L) was determined in spontaneously contracting strips or in strips contracted tonically with a protein kinase C activator (-)-indolactam V in the presence of H1 receptor antagonist (S[+]-chlorpheniramine maleate), H2 receptor antagonist (cimetidine), or solvent. RESULTS: Histamine increased spontaneous phasic myometrial contractions in a concentration-dependent manner. H1, but not H2, receptor antagonist significantly attenuated the response to histamine. Histamine significantly reduced tonic contractions of uterine strips induced by indolactam V. H1 histamine receptor antagonist abolished relaxation, whereas H2 histamine receptor antagonist had no effect. CONCLUSION: Histamine increases spontaneous, but inhibits tonic, contractions of uterine strips from term pregnant nonlaboring women. Both effects are mediated through activation of H1 receptors.",

keywords = "Contractility, Histamine, Histamine receptors, Human myometrium, Pregnancy",

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AU - Vedernikov, Yuri P.

AU - Saade, George R.

AU - Romero, Roberto

AU - Garfield, Robert E.

PY - 2003/3/1

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N2 - OBJECTIVE: To enhance our understanding of the uterotonic effect of histamine, we compared the effects of histamine on spontaneous phasic and tonic contractile activity of uterine strips from term pregnant nonlaboring women. STUDY DESIGN: Longitudinal uterine strips were used from the lower uterine segment of term pregnant nonlaboring women undergoing elective cesarean section. The concentration-response relationship to histamine (10-8 to 10-4 mol/L) was determined in spontaneously contracting strips or in strips contracted tonically with a protein kinase C activator (-)-indolactam V in the presence of H1 receptor antagonist (S[+]-chlorpheniramine maleate), H2 receptor antagonist (cimetidine), or solvent. RESULTS: Histamine increased spontaneous phasic myometrial contractions in a concentration-dependent manner. H1, but not H2, receptor antagonist significantly attenuated the response to histamine. Histamine significantly reduced tonic contractions of uterine strips induced by indolactam V. H1 histamine receptor antagonist abolished relaxation, whereas H2 histamine receptor antagonist had no effect. CONCLUSION: Histamine increases spontaneous, but inhibits tonic, contractions of uterine strips from term pregnant nonlaboring women. Both effects are mediated through activation of H1 receptors.

AB - OBJECTIVE: To enhance our understanding of the uterotonic effect of histamine, we compared the effects of histamine on spontaneous phasic and tonic contractile activity of uterine strips from term pregnant nonlaboring women. STUDY DESIGN: Longitudinal uterine strips were used from the lower uterine segment of term pregnant nonlaboring women undergoing elective cesarean section. The concentration-response relationship to histamine (10-8 to 10-4 mol/L) was determined in spontaneously contracting strips or in strips contracted tonically with a protein kinase C activator (-)-indolactam V in the presence of H1 receptor antagonist (S[+]-chlorpheniramine maleate), H2 receptor antagonist (cimetidine), or solvent. RESULTS: Histamine increased spontaneous phasic myometrial contractions in a concentration-dependent manner. H1, but not H2, receptor antagonist significantly attenuated the response to histamine. Histamine significantly reduced tonic contractions of uterine strips induced by indolactam V. H1 histamine receptor antagonist abolished relaxation, whereas H2 histamine receptor antagonist had no effect. CONCLUSION: Histamine increases spontaneous, but inhibits tonic, contractions of uterine strips from term pregnant nonlaboring women. Both effects are mediated through activation of H1 receptors.

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KW - Histamine

KW - Histamine receptors

KW - Human myometrium

KW - Pregnancy

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Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women

Abstract

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