Effect of human gamma interferon on yellow fever virus infection

J. I. Arroyo, S. A. Apperson, C. B. Cropp, B. J. Marafino, T. P. Monath, R. B. Tesh, R. E. Shope, M. A. Garcia-Blanco

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We studied yellow fever virus infection in two species of monkey: Saimiri sciureus (squirrel monkeys) and Macaca mulatta (rhesus monkeys). Human gamma interferon was administered intravenously in five equal doses, one was given 24 hr before infection followed by four doses 24 hr apart. Interferon reduced the levels and duration of viremia and the severity of hepatitis in squirrel monkeys. Inteferon prolonged survival time and delayed the appearance of viremia and hepatitis in infected rhesus monkeys, but it did not change overall mortality.

Original languageEnglish (US)
Pages (from-to)647-650
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume38
Issue number3
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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    Arroyo, J. I., Apperson, S. A., Cropp, C. B., Marafino, B. J., Monath, T. P., Tesh, R. B., Shope, R. E., & Garcia-Blanco, M. A. (1988). Effect of human gamma interferon on yellow fever virus infection. American Journal of Tropical Medicine and Hygiene, 38(3), 647-650.