Effect of human gamma interferon on yellow fever virus infection

J. I. Arroyo; S. A. Apperson; C. B. Cropp; B. J. Marafino; T. P. Monath; R. B. Tesh; R. E. Shope; M. A. Garcia-Blanco

Effect of human gamma interferon on yellow fever virus infection

J. I. Arroyo, S. A. Apperson, C. B. Cropp, B. J. Marafino, T. P. Monath, R. B. Tesh, R. E. Shope, M. A. Garcia-Blanco

Research output: Contribution to journal › Article › peer-review

Abstract

We studied yellow fever virus infection in two species of monkey: Saimiri sciureus (squirrel monkeys) and Macaca mulatta (rhesus monkeys). Human gamma interferon was administered intravenously in five equal doses, one was given 24 hr before infection followed by four doses 24 hr apart. Interferon reduced the levels and duration of viremia and the severity of hepatitis in squirrel monkeys. Inteferon prolonged survival time and delayed the appearance of viremia and hepatitis in infected rhesus monkeys, but it did not change overall mortality.

Original language	English (US)
Pages (from-to)	647-650
Number of pages	4
Journal	American Journal of Tropical Medicine and Hygiene
Volume	38
Issue number	3
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Infectious Diseases
Virology
Parasitology

Cite this

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title = "Effect of human gamma interferon on yellow fever virus infection",

abstract = "We studied yellow fever virus infection in two species of monkey: Saimiri sciureus (squirrel monkeys) and Macaca mulatta (rhesus monkeys). Human gamma interferon was administered intravenously in five equal doses, one was given 24 hr before infection followed by four doses 24 hr apart. Interferon reduced the levels and duration of viremia and the severity of hepatitis in squirrel monkeys. Inteferon prolonged survival time and delayed the appearance of viremia and hepatitis in infected rhesus monkeys, but it did not change overall mortality.",

author = "Arroyo, {J. I.} and Apperson, {S. A.} and Cropp, {C. B.} and Marafino, {B. J.} and Monath, {T. P.} and Tesh, {R. B.} and Shope, {R. E.} and Garcia-Blanco, {M. A.}",

year = "1988",

language = "English (US)",

volume = "38",

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T1 - Effect of human gamma interferon on yellow fever virus infection

AU - Arroyo, J. I.

AU - Apperson, S. A.

AU - Cropp, C. B.

AU - Marafino, B. J.

AU - Monath, T. P.

AU - Tesh, R. B.

AU - Shope, R. E.

AU - Garcia-Blanco, M. A.

PY - 1988

Y1 - 1988

N2 - We studied yellow fever virus infection in two species of monkey: Saimiri sciureus (squirrel monkeys) and Macaca mulatta (rhesus monkeys). Human gamma interferon was administered intravenously in five equal doses, one was given 24 hr before infection followed by four doses 24 hr apart. Interferon reduced the levels and duration of viremia and the severity of hepatitis in squirrel monkeys. Inteferon prolonged survival time and delayed the appearance of viremia and hepatitis in infected rhesus monkeys, but it did not change overall mortality.

AB - We studied yellow fever virus infection in two species of monkey: Saimiri sciureus (squirrel monkeys) and Macaca mulatta (rhesus monkeys). Human gamma interferon was administered intravenously in five equal doses, one was given 24 hr before infection followed by four doses 24 hr apart. Interferon reduced the levels and duration of viremia and the severity of hepatitis in squirrel monkeys. Inteferon prolonged survival time and delayed the appearance of viremia and hepatitis in infected rhesus monkeys, but it did not change overall mortality.

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AN - SCOPUS:0023904753

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JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 3

ER -

Effect of human gamma interferon on yellow fever virus infection

Abstract

ASJC Scopus subject areas

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