Effect of hypoproteinemia on pulmonary and soft tissue edema formation.

B. A. Harms, George Kramer, B. I. Bodai, R. H. Demling

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The effect of acute hypoproteinemia on the rate of fluid flux across the pulmonary and soft tissue microcirculation was studied in the unanesthetized sheep. Lymph flow was used to monitor fluid flux, a protein depletion of 30-50% of baseline value was produced by plasmapheresis. Vascular hydrostatic pressures and cardiac output were maintained constant with crystalloid infusion. The measured oncotic pressure in plasma, pi rho rapidly decreased as did the oncotic gradient between plasma and lymph. Lung and soft tissue lymph flow increased 2- to 3-fold immediately after protein depletion. Lung interstitial oncotic pressure, pi L, as measured in lymph, decreased to return the oncotic gradient and lymph flow to baseline by 24 h. Soft tissue oncotic gradient also returned to baseline by 24 h, but lymph flow remained significantly elevated for the next 48 h, indicating an increase in fluid flux unrelated to changes in oncotic pressure. Lymph flow rapidly returned to baseline when protein was returned. Protein depletion may alter the soft tissue interstitial matrix, allowing for edema formation. More effective mechanisms prevent this from occurring in the lung.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
JournalCritical Care Medicine
Volume9
Issue number7
StatePublished - Jul 1981
Externally publishedYes

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Hypoproteinemia
Lymph
Edema
Lung
Pressure
Proteins
Hydrostatic Pressure
Plasmapheresis
Microcirculation
Cardiac Output
Blood Vessels
Sheep

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Harms, B. A., Kramer, G., Bodai, B. I., & Demling, R. H. (1981). Effect of hypoproteinemia on pulmonary and soft tissue edema formation. Critical Care Medicine, 9(7), 503-508.

Effect of hypoproteinemia on pulmonary and soft tissue edema formation. / Harms, B. A.; Kramer, George; Bodai, B. I.; Demling, R. H.

In: Critical Care Medicine, Vol. 9, No. 7, 07.1981, p. 503-508.

Research output: Contribution to journalArticle

Harms, BA, Kramer, G, Bodai, BI & Demling, RH 1981, 'Effect of hypoproteinemia on pulmonary and soft tissue edema formation.', Critical Care Medicine, vol. 9, no. 7, pp. 503-508.
Harms, B. A. ; Kramer, George ; Bodai, B. I. ; Demling, R. H. / Effect of hypoproteinemia on pulmonary and soft tissue edema formation. In: Critical Care Medicine. 1981 ; Vol. 9, No. 7. pp. 503-508.
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