Effect of ibuprofen on the inflammatory response to surgical wounds

Yuan Lin Dong, R. Y. Declan Fleming, Tina Z. Yan, David N. Herndon, J. Paul Waymack

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Patients suffering severe trauma frequently become immunosuppressed following injury. This can predispose patients to infectious sequelae. Biochemically, these patients synthesize excessive quantities of cyclooxygenase products (prostaglandins). It has been hypothesized that the prostaglandins cause the immunosuppression and that inhibition of the cycloexygenase enzyme could thus prevent the immunosuppression. We investigated the effect of the cyclooxygenase inhibitor ibuprofen on the inflammatory response. Rats were subjected to a 30% total body surface area burn and were administered either ibuprofen for a period of 7 days or 14 days, or were administered the carrier for 14 days. The rats were then killed and multiple immunologic variables were measured. Ibuprofen was found to decrease neutrophil chemiluminescence, lymphocyte blastogenesis and helper/inducer T-lymphocyte infiltration of a sponge matrix model. The same ibuprofen protocol decreased survival in a cecal ligation and puncture model. In conclusion, the cyclooxygenase enzyme system appears to produce metabolites essential for optimal survival following traumatic injury.

Original languageEnglish (US)
Pages (from-to)340-343
Number of pages4
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume35
Issue number3
DOIs
StatePublished - Sep 1993

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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