Effect of ibuprofen on the inflammatory response to surgical wounds

Y. L. Dong, R. Y D Fleming, T. Z. Yan, David Herndon, J. P. Waymack

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Patients suffering severe trauma frequently become immunosuppressed following injury. This can predispose patients to infectious sequelae. Biochemically, these patients synthesize excessive quantities of cyclooxygenase products (prostaglandins). It has been hypothesized that the prostaglandins cause the immunosuppression and that inhibition of the cyclooxygenase enzyme could thus prevent the immunosuppression. We investigated the effect of the cyclooxygenase inhibitor ibuprofen on the inflammatory response. Rats were subjected to a 30% total body surface area burn and were administered either ibuprofen for a period of 7 days or 14 days, or were administered the carrier for 14 days. The rats were then killed and multiple immunologic variables were measured. Ibuprofen was found to decrease neutrophil chemiluminescence, lymphocyte blastogenesis, and helper/inducer T-lymphocyte infiltration of a sponge matrix model. The same ibuprofen protocol decreased survival in a cecal ligation and puncture model. In conclusion, the cyclooxygenase enzyme system appears to produce metabolites essential for optimal survival following traumatic injury.

Original languageEnglish (US)
Pages (from-to)340-343
Number of pages4
JournalJournal of Trauma
Volume35
Issue number3
StatePublished - 1993

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Ibuprofen
Prostaglandin-Endoperoxide Synthases
Immunosuppression
Wounds and Injuries
Survival
Cyclooxygenase Inhibitors
Body Surface Area
Porifera
Enzymes
Lymphocyte Activation
Helper-Inducer T-Lymphocytes
Luminescence
Punctures
Prostaglandins
Ligation
Neutrophils
Lymphocytes
Surgical Wound

ASJC Scopus subject areas

  • Surgery

Cite this

Dong, Y. L., Fleming, R. Y. D., Yan, T. Z., Herndon, D., & Waymack, J. P. (1993). Effect of ibuprofen on the inflammatory response to surgical wounds. Journal of Trauma, 35(3), 340-343.

Effect of ibuprofen on the inflammatory response to surgical wounds. / Dong, Y. L.; Fleming, R. Y D; Yan, T. Z.; Herndon, David; Waymack, J. P.

In: Journal of Trauma, Vol. 35, No. 3, 1993, p. 340-343.

Research output: Contribution to journalArticle

Dong, YL, Fleming, RYD, Yan, TZ, Herndon, D & Waymack, JP 1993, 'Effect of ibuprofen on the inflammatory response to surgical wounds', Journal of Trauma, vol. 35, no. 3, pp. 340-343.
Dong YL, Fleming RYD, Yan TZ, Herndon D, Waymack JP. Effect of ibuprofen on the inflammatory response to surgical wounds. Journal of Trauma. 1993;35(3):340-343.
Dong, Y. L. ; Fleming, R. Y D ; Yan, T. Z. ; Herndon, David ; Waymack, J. P. / Effect of ibuprofen on the inflammatory response to surgical wounds. In: Journal of Trauma. 1993 ; Vol. 35, No. 3. pp. 340-343.
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