Effect of ibuprofen on thermal injury with smoke inhalation

H. Sakurai, Csaba Szabo, L. D. Traber, D. L. Traber

Research output: Contribution to journalArticle

Abstract

Ibuprofen inhibits cyclooxygenase as well as the activity of neutrophils. We determined the effect of ibuprofen on the pathophysiological changes which occur after burn and smoke inhalation. Five-day after surgical preparation, 12 sheep underwent a 40% 3° burn, given 48 breaths of cotton smoke, were mechanically ventilated for the next 24 hrs in the awake state and resuscitated with Ringer's solution. One hour after injury, they were randomized into 2 groups. The Control group (n=6) was given lactated Riger's solution alone and ibuprofen group (n=6) was given a 12 mg/kg bolus injection and 6 mg/kg/hr a continuous venous infusion of ibuprofen with lactated Ringer's solution. There was an increase in lung lymph flow and reduced PaO2 in the Control group. Ibuprofen attenuated the decrease in P/F ratio, but not the edema. Plasma nitrite/nitrate was increased in the Control group but not in the ibuprofen group suggesting that that ibuprofen has beneficial and detrimental actions. (Values are mean ± SEM, *=P<0.05) variable group baseline 6 hr 96hr P/F ratio Control 481 ± 20 472 ± 51 168 ± 65*(mmHg) Ibuprofen 451 ± 12 429 ± 63 222 ± 48*Lymph Flow Control 4.7 ± 0.4 10.8 ± 3.2 17.5 ± 8.5*(ml/min) Ibuprofen 6.3 ± 1.0 17.5 ± 5.2 30.0 ± 8.5*nitrite/nitrate Control 8.4 ± 2.2 15.7 ± 2.3 23.0 ± 5.0*(μM) Ibuprofen 9.1 ± 2.5 11.6 ± 3.3 1 8.2 ± 4.6 1.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

Smoke Inhalation Injury
heat injury
ibuprofen
Ibuprofen
smoke
Smoke
breathing
Hot Temperature
lymph flow
Lymph
Nitrites
Nitrates
nitrites
Control Groups
Inhalation Burns
nitrates
prostaglandin synthase
Prostaglandin-Endoperoxide Synthases
Flow control
edema

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Sakurai, H., Szabo, C., Traber, L. D., & Traber, D. L. (1997). Effect of ibuprofen on thermal injury with smoke inhalation. FASEB Journal, 11(3).

Effect of ibuprofen on thermal injury with smoke inhalation. / Sakurai, H.; Szabo, Csaba; Traber, L. D.; Traber, D. L.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Sakurai, H, Szabo, C, Traber, LD & Traber, DL 1997, 'Effect of ibuprofen on thermal injury with smoke inhalation', FASEB Journal, vol. 11, no. 3.
Sakurai H, Szabo C, Traber LD, Traber DL. Effect of ibuprofen on thermal injury with smoke inhalation. FASEB Journal. 1997;11(3).
Sakurai, H. ; Szabo, Csaba ; Traber, L. D. ; Traber, D. L. / Effect of ibuprofen on thermal injury with smoke inhalation. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
@article{2ce861444a3e4bb7b72b5b2e9a7f38a1,
title = "Effect of ibuprofen on thermal injury with smoke inhalation",
abstract = "Ibuprofen inhibits cyclooxygenase as well as the activity of neutrophils. We determined the effect of ibuprofen on the pathophysiological changes which occur after burn and smoke inhalation. Five-day after surgical preparation, 12 sheep underwent a 40{\%} 3° burn, given 48 breaths of cotton smoke, were mechanically ventilated for the next 24 hrs in the awake state and resuscitated with Ringer's solution. One hour after injury, they were randomized into 2 groups. The Control group (n=6) was given lactated Riger's solution alone and ibuprofen group (n=6) was given a 12 mg/kg bolus injection and 6 mg/kg/hr a continuous venous infusion of ibuprofen with lactated Ringer's solution. There was an increase in lung lymph flow and reduced PaO2 in the Control group. Ibuprofen attenuated the decrease in P/F ratio, but not the edema. Plasma nitrite/nitrate was increased in the Control group but not in the ibuprofen group suggesting that that ibuprofen has beneficial and detrimental actions. (Values are mean ± SEM, *=P<0.05) variable group baseline 6 hr 96hr P/F ratio Control 481 ± 20 472 ± 51 168 ± 65*(mmHg) Ibuprofen 451 ± 12 429 ± 63 222 ± 48*Lymph Flow Control 4.7 ± 0.4 10.8 ± 3.2 17.5 ± 8.5*(ml/min) Ibuprofen 6.3 ± 1.0 17.5 ± 5.2 30.0 ± 8.5*nitrite/nitrate Control 8.4 ± 2.2 15.7 ± 2.3 23.0 ± 5.0*(μM) Ibuprofen 9.1 ± 2.5 11.6 ± 3.3 1 8.2 ± 4.6 1.",
author = "H. Sakurai and Csaba Szabo and Traber, {L. D.} and Traber, {D. L.}",
year = "1997",
language = "English (US)",
volume = "11",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "3",

}

TY - JOUR

T1 - Effect of ibuprofen on thermal injury with smoke inhalation

AU - Sakurai, H.

AU - Szabo, Csaba

AU - Traber, L. D.

AU - Traber, D. L.

PY - 1997

Y1 - 1997

N2 - Ibuprofen inhibits cyclooxygenase as well as the activity of neutrophils. We determined the effect of ibuprofen on the pathophysiological changes which occur after burn and smoke inhalation. Five-day after surgical preparation, 12 sheep underwent a 40% 3° burn, given 48 breaths of cotton smoke, were mechanically ventilated for the next 24 hrs in the awake state and resuscitated with Ringer's solution. One hour after injury, they were randomized into 2 groups. The Control group (n=6) was given lactated Riger's solution alone and ibuprofen group (n=6) was given a 12 mg/kg bolus injection and 6 mg/kg/hr a continuous venous infusion of ibuprofen with lactated Ringer's solution. There was an increase in lung lymph flow and reduced PaO2 in the Control group. Ibuprofen attenuated the decrease in P/F ratio, but not the edema. Plasma nitrite/nitrate was increased in the Control group but not in the ibuprofen group suggesting that that ibuprofen has beneficial and detrimental actions. (Values are mean ± SEM, *=P<0.05) variable group baseline 6 hr 96hr P/F ratio Control 481 ± 20 472 ± 51 168 ± 65*(mmHg) Ibuprofen 451 ± 12 429 ± 63 222 ± 48*Lymph Flow Control 4.7 ± 0.4 10.8 ± 3.2 17.5 ± 8.5*(ml/min) Ibuprofen 6.3 ± 1.0 17.5 ± 5.2 30.0 ± 8.5*nitrite/nitrate Control 8.4 ± 2.2 15.7 ± 2.3 23.0 ± 5.0*(μM) Ibuprofen 9.1 ± 2.5 11.6 ± 3.3 1 8.2 ± 4.6 1.

AB - Ibuprofen inhibits cyclooxygenase as well as the activity of neutrophils. We determined the effect of ibuprofen on the pathophysiological changes which occur after burn and smoke inhalation. Five-day after surgical preparation, 12 sheep underwent a 40% 3° burn, given 48 breaths of cotton smoke, were mechanically ventilated for the next 24 hrs in the awake state and resuscitated with Ringer's solution. One hour after injury, they were randomized into 2 groups. The Control group (n=6) was given lactated Riger's solution alone and ibuprofen group (n=6) was given a 12 mg/kg bolus injection and 6 mg/kg/hr a continuous venous infusion of ibuprofen with lactated Ringer's solution. There was an increase in lung lymph flow and reduced PaO2 in the Control group. Ibuprofen attenuated the decrease in P/F ratio, but not the edema. Plasma nitrite/nitrate was increased in the Control group but not in the ibuprofen group suggesting that that ibuprofen has beneficial and detrimental actions. (Values are mean ± SEM, *=P<0.05) variable group baseline 6 hr 96hr P/F ratio Control 481 ± 20 472 ± 51 168 ± 65*(mmHg) Ibuprofen 451 ± 12 429 ± 63 222 ± 48*Lymph Flow Control 4.7 ± 0.4 10.8 ± 3.2 17.5 ± 8.5*(ml/min) Ibuprofen 6.3 ± 1.0 17.5 ± 5.2 30.0 ± 8.5*nitrite/nitrate Control 8.4 ± 2.2 15.7 ± 2.3 23.0 ± 5.0*(μM) Ibuprofen 9.1 ± 2.5 11.6 ± 3.3 1 8.2 ± 4.6 1.

UR - http://www.scopus.com/inward/record.url?scp=33750140923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750140923&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33750140923

VL - 11

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 3

ER -