Effect of indomethacin in vivo on humoral and cellular immunity in humans

James Goodwin, D. S. Selinger, R. P. Messner, W. P. Reed

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We studied the effect of indomethacin on intradermal skin testing and antibody responses in humans. Since we and others have shown that prostaglandins are suppressor cell mediators, it was probable that in vivo inhibition of prostaglandin synthesis might enhance the humoral and/or cellular immune response. Administration of indomethacin (Indocin) in a dosage of 100 mg/day to 15 normal men and women resulted in a significantly increased antibody titer to A-Victoria (P <0.025) as compared with age- and sex-matched controls. There was no difference in titer to A-New Jersey. Since 90% of the subjects had antibody titers to A-Victoria before inoculation, whereas none had detectable titers to A-New Jersey, we interpret this data as suggesting that indomethacin enhances the secondary but not the primary humoral immune response. Indomethacin administration did not alter the intradermal skin test responses.

Original languageEnglish (US)
Pages (from-to)430-433
Number of pages4
JournalInfection and Immunity
Volume19
Issue number2
StatePublished - 1978
Externally publishedYes

Fingerprint

Humoral Immunity
Cellular Immunity
Indomethacin
Victoria
Prostaglandins
Intradermal Tests
Antibodies
Skin Tests
Antibody Formation
Skin

ASJC Scopus subject areas

  • Immunology

Cite this

Goodwin, J., Selinger, D. S., Messner, R. P., & Reed, W. P. (1978). Effect of indomethacin in vivo on humoral and cellular immunity in humans. Infection and Immunity, 19(2), 430-433.

Effect of indomethacin in vivo on humoral and cellular immunity in humans. / Goodwin, James; Selinger, D. S.; Messner, R. P.; Reed, W. P.

In: Infection and Immunity, Vol. 19, No. 2, 1978, p. 430-433.

Research output: Contribution to journalArticle

Goodwin, J, Selinger, DS, Messner, RP & Reed, WP 1978, 'Effect of indomethacin in vivo on humoral and cellular immunity in humans', Infection and Immunity, vol. 19, no. 2, pp. 430-433.
Goodwin, James ; Selinger, D. S. ; Messner, R. P. ; Reed, W. P. / Effect of indomethacin in vivo on humoral and cellular immunity in humans. In: Infection and Immunity. 1978 ; Vol. 19, No. 2. pp. 430-433.
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