Effect of indomethacin on ultraviolet radiation-induced recurrent herpes simplex virus disease in guinea-pigs

D. F. Bratcher, C. J. Harrison, Nigel Bourne, L. R. Stanberry, D. I. Bernstein

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Exposure to u.v. radiation increases the local level of prostaglandins which may play a role in u.v. radiation-induced herpes simplex virus (HSV) recurrences. We used the guinea-pig model of u.v. radiation-induced recurrent genital HSV-2 disease for examining the effects of indomethacin, a prostaglandin inhibitor, on u.v.-induced recurrences. In the first experiment, performed 100 days after HSV-2 inoculation, treatment with indomethacin for 5 days begun 24 h before u.v.-irradiation decreased the proportion of animals developing HSV disease recurrences from 11/13 (84.6%) to 2/13 (15.4%) (P < 0.001). In the second experiment, performed 135 days after HSV-2 inoculation, treatment with indomethacin for 5 days begun 24 h before u.v.-irradiation decreased the number of animals developing recurrences from 12/21 (57.1%) to 5/21 (23.8%) (P < 0.05). Five days of indomethacin treatment begun 4 h after u.v.-irradiation, however, did not reduce the percentage of animals developing disease recurrences but did decrease the mean number of days with recurrent lesions in animals that developed recurrences. Our data suggest that indomethacin may modify u.v. radiation-induced recurrent lesions by decreasing viral reactivation when given before u.v. radiation exposure or by reducing prostaglandin-induced immunosuppression when given before or after exposure. Future studies are needed for evaluating indomethacin prophylaxis for recurrent HSV disease when prolonged u.v. radiation exposure is anticipated.

Original languageEnglish (US)
Pages (from-to)1951-1954
Number of pages4
JournalJournal of General Virology
Volume74
Issue number9
StatePublished - 1993
Externally publishedYes

Fingerprint

Virus Diseases
Simplexvirus
Indomethacin
Guinea Pigs
Radiation
Recurrence
Human Herpesvirus 2
Prostaglandins
Herpes Genitalis
Prostaglandin Antagonists
Animal Diseases
Immunosuppression
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Bratcher, D. F., Harrison, C. J., Bourne, N., Stanberry, L. R., & Bernstein, D. I. (1993). Effect of indomethacin on ultraviolet radiation-induced recurrent herpes simplex virus disease in guinea-pigs. Journal of General Virology, 74(9), 1951-1954.

Effect of indomethacin on ultraviolet radiation-induced recurrent herpes simplex virus disease in guinea-pigs. / Bratcher, D. F.; Harrison, C. J.; Bourne, Nigel; Stanberry, L. R.; Bernstein, D. I.

In: Journal of General Virology, Vol. 74, No. 9, 1993, p. 1951-1954.

Research output: Contribution to journalArticle

Bratcher, DF, Harrison, CJ, Bourne, N, Stanberry, LR & Bernstein, DI 1993, 'Effect of indomethacin on ultraviolet radiation-induced recurrent herpes simplex virus disease in guinea-pigs', Journal of General Virology, vol. 74, no. 9, pp. 1951-1954.
Bratcher, D. F. ; Harrison, C. J. ; Bourne, Nigel ; Stanberry, L. R. ; Bernstein, D. I. / Effect of indomethacin on ultraviolet radiation-induced recurrent herpes simplex virus disease in guinea-pigs. In: Journal of General Virology. 1993 ; Vol. 74, No. 9. pp. 1951-1954.
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