Effect of inosine supplementation on aerobic and anaerobic cycling performance

Raymond D. Starling, Todd A. Trappe, Kevin R. Short, Melinda Sheffield-Moore, Alison C. Jozsi, William J. Fink, David L. Costill

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Ten competitive male cyclists completed a Wingate Bike Test (WIN), a 30- min self-paced cycling performance bout (END), and a constant load, supramaximal cycling sprint (SPN) to fatigue following 5 d of oral supplementation (5,000 mg · day-1) with inosine and placebo. Blood samples were obtained prior to and following both supplementation periods, and following each cycling test. Uric acid concentration was higher (P < 0.05) following supplementation with inosine versus placebo, but 2,3-DPG concentration was not changed. The data from WIN demonstrate that there were no significant differences in peak power (8.5 ± 0.3 vs 8.4 ± 0.3 W · kg body mass-1), end power (7.0 ± 0.3 vs 6.9 ± 0.2 W · kg body mass-1), fatigue index (18 ± 2 vs 18 ± 2%), total work completed (0.45 ± 0.02 vs 0.45 ± 0.02 kJ · kg body mass-1 · 30-s-1), and post-test lactate (12.2 ± 0.5 vs 12.9 ± 0.6 mmo1 · l-1) between the inosine and placebo trials, respectively. No difference was present in the total amount of work completed (6.1 ± 0.3 vs 6.0 ± 0.3 kJ · kg body mass-1) or post-test lactate (8.4 ± 1.0 vs 9.9 ± 1.3 mmol · l-1) during END between the inosine and placebo trials, respectively. Time to fatigue was longer (P < 0.05) during SPN for the placebo (109.7 ± 5.6 s) versus the inosine (99.7 ± 6.9 s) trial, but post-test lactate (14.8 ± 0.7 vs 14.6 ± 0.8 mmol · l-1) was not different between the treatments, respectively. These findings demonstrate that prolonged inosine supplementation does not appear to improve aerobic performance and short term power production during cycling and may actually have an ergolytic effect trader some test conditions.

Original languageEnglish (US)
Pages (from-to)1193-1198
Number of pages6
JournalMedicine and Science in Sports and Exercise
Volume28
Issue number9
StatePublished - Sep 1996
Externally publishedYes

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Inosine
Placebos
Fatigue
Lactic Acid
2,3-Diphosphoglycerate
Uric Acid

Keywords

  • (2.3)-DPG
  • FATIGUE
  • LACTATE
  • URIC ACID

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine

Cite this

Starling, R. D., Trappe, T. A., Short, K. R., Sheffield-Moore, M., Jozsi, A. C., Fink, W. J., & Costill, D. L. (1996). Effect of inosine supplementation on aerobic and anaerobic cycling performance. Medicine and Science in Sports and Exercise, 28(9), 1193-1198.

Effect of inosine supplementation on aerobic and anaerobic cycling performance. / Starling, Raymond D.; Trappe, Todd A.; Short, Kevin R.; Sheffield-Moore, Melinda; Jozsi, Alison C.; Fink, William J.; Costill, David L.

In: Medicine and Science in Sports and Exercise, Vol. 28, No. 9, 09.1996, p. 1193-1198.

Research output: Contribution to journalArticle

Starling, RD, Trappe, TA, Short, KR, Sheffield-Moore, M, Jozsi, AC, Fink, WJ & Costill, DL 1996, 'Effect of inosine supplementation on aerobic and anaerobic cycling performance', Medicine and Science in Sports and Exercise, vol. 28, no. 9, pp. 1193-1198.
Starling RD, Trappe TA, Short KR, Sheffield-Moore M, Jozsi AC, Fink WJ et al. Effect of inosine supplementation on aerobic and anaerobic cycling performance. Medicine and Science in Sports and Exercise. 1996 Sep;28(9):1193-1198.
Starling, Raymond D. ; Trappe, Todd A. ; Short, Kevin R. ; Sheffield-Moore, Melinda ; Jozsi, Alison C. ; Fink, William J. ; Costill, David L. / Effect of inosine supplementation on aerobic and anaerobic cycling performance. In: Medicine and Science in Sports and Exercise. 1996 ; Vol. 28, No. 9. pp. 1193-1198.
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