Effect of insulin-like growth factor 1 on host response to tumor

Y. L. Dong, R. Y D Fleming, K. F. Huang, David Herndon, T. Z. Yan, J. P. Waymack

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Oncology patients suffer multiple detrimental metabolic alterations. Among these are catabolism of tumor free body mass to supply nutrients to feed the tumor. This results not only in enhanced tumor growth but also poor wound healing and immunosuppression of the tumor host. Efforts are therefore being directed at finding methods for improving the nutritional status of the tumor host without enhancing tumor growth. We investigated the ability of two hormones, insulin-like growth factor-1 (IGF-1) and insulin, to improve physiologic function in tumor-bearing animals. Tumor-bearing animals received a continuous infusion of IGF-1 (2.20 mg/kg/day), insulin (820 μm/kg/day) or placebo via an osmotic minipump for 7 days. All animals were pair fed to eliminate nutritional intake as a variable. The placebo group lost 31.37 ± 4.3 g of tumor free body mass during the study period. The insulin treated group lost 26.34 ± 7.42 g and the IGF-1 group lost 5.07 ± 3.25 g (P < 0.001, ANOVA). IGF-1 treatment failed to alter plasma glucose, lactate, or total amino acid concentration and failed to alter hepatic ketone body concentrations, but did improve hepatic mitochondria redox potential. Finally, IGF-1 improved splenic weight by 110% and splenic lymphocyte count by 300%. In conclusion IGF-1 appears to offer potential in supporting tumor free host body mass without stimulating tumor growth.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalJournal of Surgical Oncology
Volume53
Issue number2
DOIs
StatePublished - 1993

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Somatomedins
Neoplasms
Insulin
Growth
Placebos
Ketone Bodies
Liver
Lymphocyte Count
Nutritional Status
Wound Healing
Immunosuppression
Oxidation-Reduction
Lactic Acid
Analysis of Variance
Mitochondria
Hormones
Amino Acids
Weights and Measures
Glucose
Food

Keywords

  • cachexia
  • insulin
  • insulin-like growth factor-1
  • mitochondrial redox potential
  • oncology

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Dong, Y. L., Fleming, R. Y. D., Huang, K. F., Herndon, D., Yan, T. Z., & Waymack, J. P. (1993). Effect of insulin-like growth factor 1 on host response to tumor. Journal of Surgical Oncology, 53(2), 121-127. https://doi.org/10.1002/jso.2930530215

Effect of insulin-like growth factor 1 on host response to tumor. / Dong, Y. L.; Fleming, R. Y D; Huang, K. F.; Herndon, David; Yan, T. Z.; Waymack, J. P.

In: Journal of Surgical Oncology, Vol. 53, No. 2, 1993, p. 121-127.

Research output: Contribution to journalArticle

Dong, YL, Fleming, RYD, Huang, KF, Herndon, D, Yan, TZ & Waymack, JP 1993, 'Effect of insulin-like growth factor 1 on host response to tumor', Journal of Surgical Oncology, vol. 53, no. 2, pp. 121-127. https://doi.org/10.1002/jso.2930530215
Dong YL, Fleming RYD, Huang KF, Herndon D, Yan TZ, Waymack JP. Effect of insulin-like growth factor 1 on host response to tumor. Journal of Surgical Oncology. 1993;53(2):121-127. https://doi.org/10.1002/jso.2930530215
Dong, Y. L. ; Fleming, R. Y D ; Huang, K. F. ; Herndon, David ; Yan, T. Z. ; Waymack, J. P. / Effect of insulin-like growth factor 1 on host response to tumor. In: Journal of Surgical Oncology. 1993 ; Vol. 53, No. 2. pp. 121-127.
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