Effect of intraventricular infusions of artificial cerebrospinal fluid on serum renin activity, aldosterone, corticosterone, and prolactin

C. Gomez Sanchez, O. B. Holland, B. A. Murry

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Renal sodium excretion has been noted to increase with intraventricular infusion of hypernatremic fluid and to decrease with infusion of hyponatremic fluid. To further explore the mechanism of these changes, serum renin activity and serum aldosterone, corticosterone, and prolactin concentration were measured after 1-hr infusion of artificial cerebrospinal fluid of varying sodium concentration and osmolality into the lateral ventricles of unanesthetized rats which had been consuming regular-sodium or low-sodium diets. Serum aldosterone and prolactin concentrations did not change significantly. Serum renin activity increased with infusion of iso-osmotic, hyponatremic fluid during regular-sodium diet. Serum corticosterone concentration increased during low-sodium diet with infusion of iso-osmotic, hyponatremic and hyperosmotic, hypernatremic fluid. The failure of serum aldosterone concentration to increase concomitant with increase in serum renin activity and corticosterone concentration suggests that additional central nervous system factor(s) may influence aldosterone secretion. The mechanism for the changes in renal sodium excretion during intraventricular infusion remains uncertain, but it does not appear to be mediated through aldosterone or prolactin.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - 1977


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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