Effect of isoprinosine on lymphocyte proliferation and natural killer cell activity following thermal injury

Harbans Singh, David Herndon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of in vivo administration of Isoprinosine (ISO) on, i) the proliferation of splenic lymphocytes in response to the T-cell mitogen, concanavalin-A (Con-A) and, ii) the natural killer (NK) cell cytotoxicity was studied following a full skin thickness burn injury in a rat model. Administration of ISO (100 mg/kg body wt/day) twice daily, resulted in significant augmentation of the proliferative responses of lymphocytes compared to non-treated burned animals, at 7 days post injury. However, it did not effect the lymphoproliferation at 14 days post injury, the time period at which a complete suppression of lymphocyte proliferation was observed in burned non-treated animals. Also, the proliferation of lymphocytes from normal nonburned animals was not affected by treatment with ISO. ISO treatment of the burned animals resulted in a significant increase in the NK cytotoxicity compared to non-treated burned animals. As with Con-A responses, ISO administered to control nonburned animals did not have any effect on NK cell cytotoxicity. Our studies thus indicate that ISO can be a potential immunomodulator of suppressed immune funtion following thermal injury, particularly in patients whose lymphocyte responses to T cell mitogen Con-A are not completely suppressed.

Original languageEnglish (US)
Pages (from-to)631-644
Number of pages14
JournalImmunopharmacology and Immunotoxicology
Volume11
Issue number4
DOIs
StatePublished - 1989

Fingerprint

Inosine Pranobex
Lymphocytes
Natural Killer Cells
Animals
Hot Temperature
Wounds and Injuries
Cytotoxicity
Concanavalin A
T-cells
Mitogens
T-Lymphocytes
Population Growth
Immunologic Factors
Rats
Skin
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Effect of isoprinosine on lymphocyte proliferation and natural killer cell activity following thermal injury. / Singh, Harbans; Herndon, David.

In: Immunopharmacology and Immunotoxicology, Vol. 11, No. 4, 1989, p. 631-644.

Research output: Contribution to journalArticle

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