Effect of L-arginine on adrenal and renal blood flows during hemorrhage in cats

Z. Benyo, C. Szabo, C. Csaki, M. Wahl, A. G.B. Kovach, P. Sandor

    Research output: Contribution to journalArticle

    3 Scopus citations

    Abstract

    Our earlier studies have shown development of endothelial dysfunction in the feline renal artery during hemorrhagic hypotension. Because L-arginine (L-Arg), the precursor of nitric oxide (NO), reportedly improves endothelial function in several pathophysiological states including hypotension, we investigated its possible beneficial effect on the adrenal and renal circulations during hemorrhagic hypotension in anesthetized, ventilated cats. Hypotension (mean arterial pressure 50 mm Hg) significantly increased vascular resistance and decreased blood flow (radiolabeled microspheres) in both adrenal and renal cortices. L, Arg (30 mg/kg bolus, 10 mg/kg/min infusion, i.v.) had no significant hemodynamic effects in normotension but prevented the increase of the vascular resistance and improved blood flow in the adrenal cortex during hypotension. In the kidney, L-Arg also prevented hemorrhage-induced vasoconstriction, although its effect on blood flow did not reach significance. The NO synthase inhibitor N(G)-nitro-L-arginine (30 mg/kg bolus, 1 mg/kg/min infusion, i.v.) increased adrenal and renal vascular resistances to a similar extent as that observed during hypotension. It thus seems that an L-Arg-reversible dysfunction of the endothelial NO-synthesizing pathway contributes to hemorrhage-induced adrenal and renal vasoconstriction.

    Original languageEnglish (US)
    Pages (from-to)S221-S223
    JournalKidney International, Supplement
    Volume54
    Issue number67
    StatePublished - Jan 1 1998

    Keywords

    • Endothelium
    • Hemorrhagic hypotension
    • N(G)-nitro-L-arginine
    • Nitric oxide
    • Shock
    • Vascular resistance
    • Vasoconstriction

    ASJC Scopus subject areas

    • Nephrology

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  • Cite this

    Benyo, Z., Szabo, C., Csaki, C., Wahl, M., Kovach, A. G. B., & Sandor, P. (1998). Effect of L-arginine on adrenal and renal blood flows during hemorrhage in cats. Kidney International, Supplement, 54(67), S221-S223.