Effect of L-arginine on adrenal and renal blood flows during hemorrhage in cats

Z. Benyo, Csaba Szabo, C. Csaki, M. Wahl, A. G B Kovach, P. Sandor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Our earlier studies have shown development of endothelial dysfunction in the feline renal artery during hemorrhagic hypotension. Because L-arginine (L-Arg), the precursor of nitric oxide (NO), reportedly improves endothelial function in several pathophysiological states including hypotension, we investigated its possible beneficial effect on the adrenal and renal circulations during hemorrhagic hypotension in anesthetized, ventilated cats. Hypotension (mean arterial pressure 50 mm Hg) significantly increased vascular resistance and decreased blood flow (radiolabeled microspheres) in both adrenal and renal cortices. L, Arg (30 mg/kg bolus, 10 mg/kg/min infusion, i.v.) had no significant hemodynamic effects in normotension but prevented the increase of the vascular resistance and improved blood flow in the adrenal cortex during hypotension. In the kidney, L-Arg also prevented hemorrhage-induced vasoconstriction, although its effect on blood flow did not reach significance. The NO synthase inhibitor N(G)-nitro-L-arginine (30 mg/kg bolus, 1 mg/kg/min infusion, i.v.) increased adrenal and renal vascular resistances to a similar extent as that observed during hypotension. It thus seems that an L-Arg-reversible dysfunction of the endothelial NO-synthesizing pathway contributes to hemorrhage-induced adrenal and renal vasoconstriction.

Original languageEnglish (US)
JournalKidney International, Supplement
Volume54
Issue number67
StatePublished - 1998
Externally publishedYes

Fingerprint

Renal Circulation
Hypotension
Arginine
Cats
Hemorrhage
Vascular Resistance
Kidney
Adrenal Cortex
Vasoconstriction
Nitric Oxide
Felidae
Renal Artery
Microspheres
Nitric Oxide Synthase
Arterial Pressure
Hemodynamics

Keywords

  • Endothelium
  • Hemorrhagic hypotension
  • N(G)-nitro-L-arginine
  • Nitric oxide
  • Shock
  • Vascular resistance
  • Vasoconstriction

ASJC Scopus subject areas

  • Nephrology

Cite this

Benyo, Z., Szabo, C., Csaki, C., Wahl, M., Kovach, A. G. B., & Sandor, P. (1998). Effect of L-arginine on adrenal and renal blood flows during hemorrhage in cats. Kidney International, Supplement, 54(67).

Effect of L-arginine on adrenal and renal blood flows during hemorrhage in cats. / Benyo, Z.; Szabo, Csaba; Csaki, C.; Wahl, M.; Kovach, A. G B; Sandor, P.

In: Kidney International, Supplement, Vol. 54, No. 67, 1998.

Research output: Contribution to journalArticle

Benyo, Z, Szabo, C, Csaki, C, Wahl, M, Kovach, AGB & Sandor, P 1998, 'Effect of L-arginine on adrenal and renal blood flows during hemorrhage in cats', Kidney International, Supplement, vol. 54, no. 67.
Benyo, Z. ; Szabo, Csaba ; Csaki, C. ; Wahl, M. ; Kovach, A. G B ; Sandor, P. / Effect of L-arginine on adrenal and renal blood flows during hemorrhage in cats. In: Kidney International, Supplement. 1998 ; Vol. 54, No. 67.
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