Effect of l-dopa administration on rabbit lens and erythrocytes

Satish Srivastava, Ernest Beutler

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Effect of feeding high dosage of l-dopa and a dopa decarboxylase inhibitor, l-isomer of α-hydrazino-α-(3,4-dihydroxybenzyl) propionic acid monohydrate, on the red blood cells and lens of rabbit eye was studied. The plasma l-dopa level increased after feeding l-dopa to rabbits. However, feeding dopa decarboxylase inhibitor along with l-dopa prolonged the persistence of high levels of l-dopa in plasma. Only very small amounts of l-dopa could be detected in the aqueous humor of rabbits fed l-dopa + inhibitor. Dopa decarboxylase activity was totally absent from the lens and was very slight in the red cells. l-Dopa alone or along with dopa decarboxylase inhibitor did not have any effect on the red cell survival in rabbits. Even 5 times the physiological level of plasma l-dopa found after feeding l-dopa + dopa decarboxylase inhibitor did not have any appreciable effect on red cell glutathione in vitro. Feeding l-dopa alone or l-dopa with dopa decarboxylase inhibitor has no cataractogenic effect.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalBiochemical Medicine
Volume5
Issue number4
DOIs
StatePublished - 1971
Externally publishedYes

Fingerprint

Dihydroxyphenylalanine
Lenses
Erythrocytes
Dopa Decarboxylase
Rabbits
Cells
Plasmas
Crystalline Lens
Aqueous Humor
Isomers
Glutathione
Cell Survival
Blood

ASJC Scopus subject areas

  • Biochemistry

Cite this

Effect of l-dopa administration on rabbit lens and erythrocytes. / Srivastava, Satish; Beutler, Ernest.

In: Biochemical Medicine, Vol. 5, No. 4, 1971, p. 317-324.

Research output: Contribution to journalArticle

Srivastava, Satish ; Beutler, Ernest. / Effect of l-dopa administration on rabbit lens and erythrocytes. In: Biochemical Medicine. 1971 ; Vol. 5, No. 4. pp. 317-324.
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