Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets

N. Gualde, D. Atluru, James Goodwin

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

The lipoxygenase products LTB4 and 15 HPETE have been reported to stimulate T suppressor cell function and also to inhibit [3H]thymidine incorporation into mitogen-stimulated T cells. This present report documents that although these compounds do indeed inhibit [3H]thymidine incorporation into unfractionated T cells, they significantly enhance [3H]thymidine incorporation into T cell preparation enriched for cells bearing the cytotoxic suppressor cell phenotype identified by the OKT8 monoclonal antibody. The mitogen response of T cells enriched for OKT4+ helper-inducer cells is inhibited in a manner similar to the response of unfractionated T cells. Thus, LTB4 and 15 HPETE stimulate both the function and the proliferation of the cytotoxic-suppressor T cell subset.

Original languageEnglish
Pages (from-to)1125-1129
Number of pages5
JournalJournal of Immunology
Volume134
Issue number2
StatePublished - 1985
Externally publishedYes

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Arachidonate Lipoxygenases
T-Lymphocyte Subsets
T-Lymphocytes
Thymidine
Leukotriene B4
Helper-Inducer T-Lymphocytes
Mitogens
Lipoxygenase
Monoclonal Antibodies
Phenotype

ASJC Scopus subject areas

  • Immunology

Cite this

Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets. / Gualde, N.; Atluru, D.; Goodwin, James.

In: Journal of Immunology, Vol. 134, No. 2, 1985, p. 1125-1129.

Research output: Contribution to journalArticle

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