Abstract
The lipoxygenase products LTB4 and 15 HPETE have been reported to stimulate T suppressor cell function and also to inhibit [3H]thymidine incorporation into mitogen-stimulated T cells. This present report documents that although these compounds do indeed inhibit [3H]thymidine incorporation into unfractionated T cells, they significantly enhance [3H]thymidine incorporation into T cell preparation enriched for cells bearing the cytotoxic suppressor cell phenotype identified by the OKT8 monoclonal antibody. The mitogen response of T cells enriched for OKT4+ helper-inducer cells is inhibited in a manner similar to the response of unfractionated T cells. Thus, LTB4 and 15 HPETE stimulate both the function and the proliferation of the cytotoxic-suppressor T cell subset.
| Original language | English |
|---|---|
| Pages (from-to) | 1125-1129 |
| Number of pages | 5 |
| Journal | Journal of Immunology |
| Volume | 134 |
| Issue number | 2 |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
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Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets. / Gualde, N.; Atluru, D.; Goodwin, James.
In: Journal of Immunology, Vol. 134, No. 2, 1985, p. 1125-1129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets
AU - Gualde, N.
AU - Atluru, D.
AU - Goodwin, James
PY - 1985
Y1 - 1985
N2 - The lipoxygenase products LTB4 and 15 HPETE have been reported to stimulate T suppressor cell function and also to inhibit [3H]thymidine incorporation into mitogen-stimulated T cells. This present report documents that although these compounds do indeed inhibit [3H]thymidine incorporation into unfractionated T cells, they significantly enhance [3H]thymidine incorporation into T cell preparation enriched for cells bearing the cytotoxic suppressor cell phenotype identified by the OKT8 monoclonal antibody. The mitogen response of T cells enriched for OKT4+ helper-inducer cells is inhibited in a manner similar to the response of unfractionated T cells. Thus, LTB4 and 15 HPETE stimulate both the function and the proliferation of the cytotoxic-suppressor T cell subset.
AB - The lipoxygenase products LTB4 and 15 HPETE have been reported to stimulate T suppressor cell function and also to inhibit [3H]thymidine incorporation into mitogen-stimulated T cells. This present report documents that although these compounds do indeed inhibit [3H]thymidine incorporation into unfractionated T cells, they significantly enhance [3H]thymidine incorporation into T cell preparation enriched for cells bearing the cytotoxic suppressor cell phenotype identified by the OKT8 monoclonal antibody. The mitogen response of T cells enriched for OKT4+ helper-inducer cells is inhibited in a manner similar to the response of unfractionated T cells. Thus, LTB4 and 15 HPETE stimulate both the function and the proliferation of the cytotoxic-suppressor T cell subset.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021909161&partnerID=8YFLogxK
M3 - Article
C2 - 2981258
AN - SCOPUS:0021909161
VL - 134
SP - 1125
EP - 1129
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 2
ER -