Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets

N. Gualde, D. Atluru, J. S. Goodwin

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

The lipoxygenase products LTB4 and 15 HPETE have been reported to stimulate T suppressor cell function and also to inhibit [3H]thymidine incorporation into mitogen-stimulated T cells. This present report documents that although these compounds do indeed inhibit [3H]thymidine incorporation into unfractionated T cells, they significantly enhance [3H]thymidine incorporation into T cell preparation enriched for cells bearing the cytotoxic suppressor cell phenotype identified by the OKT8 monoclonal antibody. The mitogen response of T cells enriched for OKT4+ helper-inducer cells is inhibited in a manner similar to the response of unfractionated T cells. Thus, LTB4 and 15 HPETE stimulate both the function and the proliferation of the cytotoxic-suppressor T cell subset.

Original languageEnglish (US)
Pages (from-to)1125-1129
Number of pages5
JournalJournal of Immunology
Volume134
Issue number2
StatePublished - 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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