When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Apr 1991|
ASJC Scopus subject areas
- Clinical Neurology