Effect of long-term L-dopa administration on striatal extracellular dopamine release

Timothy Brannan, Julian Martinez-Tica, Melvin D. Yahr

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.

Original languageEnglish (US)
Pages (from-to)596-598
Number of pages3
JournalNeurology
Volume41
Issue number4
DOIs
StatePublished - Apr 1991

ASJC Scopus subject areas

  • Clinical Neurology

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