Effect of long-term L-dopa administration on striatal extracellular dopamine release

Timothy Brannan, Julian Martinez-Tica, Melvin D. Yahr

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.

Original languageEnglish (US)
Pages (from-to)596-598
Number of pages3
JournalNeurology
Volume41
Issue number4
StatePublished - Apr 1991
Externally publishedYes

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Corpus Striatum
Levodopa
Dopamine
Placebos
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Brannan, T., Martinez-Tica, J., & Yahr, M. D. (1991). Effect of long-term L-dopa administration on striatal extracellular dopamine release. Neurology, 41(4), 596-598.

Effect of long-term L-dopa administration on striatal extracellular dopamine release. / Brannan, Timothy; Martinez-Tica, Julian; Yahr, Melvin D.

In: Neurology, Vol. 41, No. 4, 04.1991, p. 596-598.

Research output: Contribution to journalArticle

Brannan, T, Martinez-Tica, J & Yahr, MD 1991, 'Effect of long-term L-dopa administration on striatal extracellular dopamine release', Neurology, vol. 41, no. 4, pp. 596-598.
Brannan T, Martinez-Tica J, Yahr MD. Effect of long-term L-dopa administration on striatal extracellular dopamine release. Neurology. 1991 Apr;41(4):596-598.
Brannan, Timothy ; Martinez-Tica, Julian ; Yahr, Melvin D. / Effect of long-term L-dopa administration on striatal extracellular dopamine release. In: Neurology. 1991 ; Vol. 41, No. 4. pp. 596-598.
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