Effect of long-term L-dopa administration on striatal extracellular dopamine release

Timothy Brannan; Julian Martinez-Tica; Melvin D. Yahr

doi:10.1212/wnl.41.4.596

Effect of long-term L-dopa administration on striatal extracellular dopamine release

Timothy Brannan, Julian Martinez-Tica, Melvin D. Yahr

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.

Original language	English (US)
Pages (from-to)	596-598
Number of pages	3
Journal	Neurology
Volume	41
Issue number	4
DOIs	https://doi.org/10.1212/wnl.41.4.596
State	Published - Apr 1991
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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title = "Effect of long-term L-dopa administration on striatal extracellular dopamine release",

abstract = "When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43\% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.",

author = "Timothy Brannan and Julian Martinez-Tica and Yahr, \{Melvin D.\}",

year = "1991",

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doi = "10.1212/wnl.41.4.596",

language = "English (US)",

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journal = "Neurology",

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AU - Brannan, Timothy

AU - Martinez-Tica, Julian

AU - Yahr, Melvin D.

PY - 1991/4

Y1 - 1991/4

N2 - When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.

AB - When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.

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M3 - Article

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AN - SCOPUS:0025884506

SN - 0028-3878

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SP - 596

EP - 598

JO - Neurology

JF - Neurology

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ER -

Effect of long-term L-dopa administration on striatal extracellular dopamine release

Abstract

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