Effect of low-dose bradykinin on glucose metabolism and nitrogen balance in surgical patients

W. H. Hartl, K. W. Jauch, T. U. Cohnert, F. W. Schildberg, David Herndon, R. R. Wolfe

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Acute effects of a low-dose bradykinin infusion (30 ng/kg per min) on carbohydrate metabolism were studied in five patients after major burn injury. Peripheral glucose uptake was not affected but glucose oxidation and alanine flux were increased by 15% and 10%, respectively. These findings are compatible with an increase in glycolytic flux by an action of bradykinin. Nineteen patients who had undergone major gastrointestinal surgery were studied in a randomised trial of chronic (6 day) bradykinin administration. Patients in the bradykinin group had a significantly improved rate of nitrogen retention (cumulative N balance, -0·014 [SE 0·064] vs -0·175 [0·048] g N/kg) in controls and significantly better nutritional indices. Manipulation of metabolism in surgical patients by bradykinin may have beneficial effects on nitrogen and protein dynamics, possibly mediated by improved aerobic and anaerobic glycolysis.

Original languageEnglish (US)
Pages (from-to)69-71
Number of pages3
JournalThe Lancet
Volume335
Issue number8681
DOIs
StatePublished - Jan 13 1990

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Bradykinin
Nitrogen
Glucose
Nutrition Assessment
Carbohydrate Metabolism
Glycolysis
Alanine
Wounds and Injuries
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hartl, W. H., Jauch, K. W., Cohnert, T. U., Schildberg, F. W., Herndon, D., & Wolfe, R. R. (1990). Effect of low-dose bradykinin on glucose metabolism and nitrogen balance in surgical patients. The Lancet, 335(8681), 69-71. https://doi.org/10.1016/0140-6736(90)90538-G

Effect of low-dose bradykinin on glucose metabolism and nitrogen balance in surgical patients. / Hartl, W. H.; Jauch, K. W.; Cohnert, T. U.; Schildberg, F. W.; Herndon, David; Wolfe, R. R.

In: The Lancet, Vol. 335, No. 8681, 13.01.1990, p. 69-71.

Research output: Contribution to journalArticle

Hartl, WH, Jauch, KW, Cohnert, TU, Schildberg, FW, Herndon, D & Wolfe, RR 1990, 'Effect of low-dose bradykinin on glucose metabolism and nitrogen balance in surgical patients', The Lancet, vol. 335, no. 8681, pp. 69-71. https://doi.org/10.1016/0140-6736(90)90538-G
Hartl WH, Jauch KW, Cohnert TU, Schildberg FW, Herndon D, Wolfe RR. Effect of low-dose bradykinin on glucose metabolism and nitrogen balance in surgical patients. The Lancet. 1990 Jan 13;335(8681):69-71. https://doi.org/10.1016/0140-6736(90)90538-G
Hartl, W. H. ; Jauch, K. W. ; Cohnert, T. U. ; Schildberg, F. W. ; Herndon, David ; Wolfe, R. R. / Effect of low-dose bradykinin on glucose metabolism and nitrogen balance in surgical patients. In: The Lancet. 1990 ; Vol. 335, No. 8681. pp. 69-71.
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