Effect of maternal body mass index on in vitro response to tocolytics in term myometrium

Giuseppe Chiossi, Maged Costantine, Ancizar Betancourt, Gary Hankins, Monica Longo, George Saade, Egle Bytautiene

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. Study Design: Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n = 7), 30-34.9 (31.8 ± 1.2; n = 16), and ≥35 (39.5 ± 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10-10 to 10-5 mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. Results: Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. Conclusion: BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume203
Issue number3
DOIs
StatePublished - Sep 2010

Fingerprint

Tocolytic Agents
Myometrium
Body Mass Index
Mothers
Nifedipine
Indomethacin
Area Under Curve
Analysis of Variance
In Vitro Techniques
Biopsy

Keywords

  • indomethacin
  • nifedipine
  • obesity
  • organ chamber
  • oxytocin
  • uterine contractility

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Effect of maternal body mass index on in vitro response to tocolytics in term myometrium. / Chiossi, Giuseppe; Costantine, Maged; Betancourt, Ancizar; Hankins, Gary; Longo, Monica; Saade, George; Bytautiene, Egle.

In: American Journal of Obstetrics and Gynecology, Vol. 203, No. 3, 09.2010.

Research output: Contribution to journalArticle

Chiossi, Giuseppe ; Costantine, Maged ; Betancourt, Ancizar ; Hankins, Gary ; Longo, Monica ; Saade, George ; Bytautiene, Egle. / Effect of maternal body mass index on in vitro response to tocolytics in term myometrium. In: American Journal of Obstetrics and Gynecology. 2010 ; Vol. 203, No. 3.
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