Effect of maternal body mass index on in vitro response to tocolytics in term myometrium

Giuseppe Chiossi; Maged M. Costantine; Ancizar Betancourt; Gary D.V. Hankins; Monica Longo; George R. Saade; Egle Bytautiene

doi:10.1016/j.ajog.2010.05.029

Effect of maternal body mass index on in vitro response to tocolytics in term myometrium

Giuseppe Chiossi, Maged M. Costantine, Ancizar Betancourt, Gary D.V. Hankins, Monica Longo, George R. Saade, Egle Bytautiene

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. Study Design: Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n = 7), 30-34.9 (31.8 ± 1.2; n = 16), and ≥35 (39.5 ± 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10^-10 to 10^-5 mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. Results: Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. Conclusion: BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.

Original language	English (US)
Pages (from-to)	261.e1-261.e5
Journal	American journal of obstetrics and gynecology
Volume	203
Issue number	3
DOIs	https://doi.org/10.1016/j.ajog.2010.05.029
State	Published - Sep 2010
Externally published	Yes

Keywords

indomethacin
nifedipine
obesity
organ chamber
oxytocin
uterine contractility

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2010.05.029

Cite this

@article{f468ee053ac54c14b2a894d8319db8f3,

title = "Effect of maternal body mass index on in vitro response to tocolytics in term myometrium",

abstract = "Objective: We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. Study Design: Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n = 7), 30-34.9 (31.8 ± 1.2; n = 16), and ≥35 (39.5 ± 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10-10 to 10-5 mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. Results: Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. Conclusion: BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.",

keywords = "indomethacin, nifedipine, obesity, organ chamber, oxytocin, uterine contractility",

author = "Giuseppe Chiossi and Costantine, {Maged M.} and Ancizar Betancourt and Hankins, {Gary D.V.} and Monica Longo and Saade, {George R.} and Egle Bytautiene",

note = "Funding Information: Financial support was provided by the Department of Obstetrics and Gynecology , University of Texas Medical Branch, Galveston, TX. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2010",

month = sep,

doi = "10.1016/j.ajog.2010.05.029",

language = "English (US)",

volume = "203",

pages = "261.e1--261.e5",

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T1 - Effect of maternal body mass index on in vitro response to tocolytics in term myometrium

AU - Chiossi, Giuseppe

AU - Costantine, Maged M.

AU - Betancourt, Ancizar

AU - Hankins, Gary D.V.

AU - Longo, Monica

AU - Saade, George R.

AU - Bytautiene, Egle

N1 - Funding Information: Financial support was provided by the Department of Obstetrics and Gynecology , University of Texas Medical Branch, Galveston, TX. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2010/9

Y1 - 2010/9

N2 - Objective: We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. Study Design: Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n = 7), 30-34.9 (31.8 ± 1.2; n = 16), and ≥35 (39.5 ± 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10-10 to 10-5 mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. Results: Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. Conclusion: BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.

AB - Objective: We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. Study Design: Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n = 7), 30-34.9 (31.8 ± 1.2; n = 16), and ≥35 (39.5 ± 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10-10 to 10-5 mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. Results: Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. Conclusion: BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.

KW - indomethacin

KW - nifedipine

KW - obesity

KW - organ chamber

KW - oxytocin

KW - uterine contractility

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Effect of maternal body mass index on in vitro response to tocolytics in term myometrium

Abstract

Keywords

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