Effect of maternal body mass index on in vitro response to tocolytics in term myometrium

Giuseppe Chiossi, Maged M. Costantine, Ancizar Betancourt, Gary D.V. Hankins, Monica Longo, George R. Saade, Egle Bytautiene

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective: We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. Study Design: Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n = 7), 30-34.9 (31.8 ± 1.2; n = 16), and ≥35 (39.5 ± 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10-10 to 10-5 mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. Results: Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. Conclusion: BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.

Original languageEnglish (US)
Pages (from-to)261.e1-261.e5
JournalAmerican journal of obstetrics and gynecology
Volume203
Issue number3
DOIs
StatePublished - Sep 2010

Keywords

  • indomethacin
  • nifedipine
  • obesity
  • organ chamber
  • oxytocin
  • uterine contractility

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Chiossi, G., Costantine, M. M., Betancourt, A., Hankins, G. D. V., Longo, M., Saade, G. R., & Bytautiene, E. (2010). Effect of maternal body mass index on in vitro response to tocolytics in term myometrium. American journal of obstetrics and gynecology, 203(3), 261.e1-261.e5. https://doi.org/10.1016/j.ajog.2010.05.029