Effect of maternal body mass index on in vitro response to tocolytics in term myometrium

Giuseppe Chiossi; Maged M. Costantine; Ancizar Betancourt; Gary D.V. Hankins; Monica Longo; George R. Saade; Egle Bytautiene

doi:10.1016/j.ajog.2010.05.029

Effect of maternal body mass index on in vitro response to tocolytics in term myometrium

Giuseppe Chiossi
, Maged M. Costantine
, Ancizar Betancourt
, Gary D.V. Hankins
, Monica Longo
, George R. Saade
, Egle Bytautiene

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. Study Design: Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n = 7), 30-34.9 (31.8 ± 1.2; n = 16), and ≥35 (39.5 ± 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10^-10 to 10^-5 mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. Results: Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. Conclusion: BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.

Original language	English (US)
Pages (from-to)	261.e1-261.e5
Journal	American journal of obstetrics and gynecology
Volume	203
Issue number	3
DOIs	https://doi.org/10.1016/j.ajog.2010.05.029
State	Published - Sep 2010
Externally published	Yes

Keywords

indomethacin
nifedipine
obesity
organ chamber
oxytocin
uterine contractility

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2010.05.029

Cite this

@article{f468ee053ac54c14b2a894d8319db8f3,

title = "Effect of maternal body mass index on in vitro response to tocolytics in term myometrium",

abstract = "Objective: We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. Study Design: Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n = 7), 30-34.9 (31.8 ± 1.2; n = 16), and ≥35 (39.5 ± 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10-10 to 10-5 mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. Results: Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. Conclusion: BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.",

keywords = "indomethacin, nifedipine, obesity, organ chamber, oxytocin, uterine contractility",

author = "Giuseppe Chiossi and Costantine, \{Maged M.\} and Ancizar Betancourt and Hankins, \{Gary D.V.\} and Monica Longo and Saade, \{George R.\} and Egle Bytautiene",

note = "Funding Information: Financial support was provided by the Department of Obstetrics and Gynecology , University of Texas Medical Branch, Galveston, TX. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2010",

month = sep,

doi = "10.1016/j.ajog.2010.05.029",

language = "English (US)",

volume = "203",

pages = "261.e1--261.e5",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

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}

TY - JOUR

T1 - Effect of maternal body mass index on in vitro response to tocolytics in term myometrium

AU - Chiossi, Giuseppe

AU - Costantine, Maged M.

AU - Betancourt, Ancizar

AU - Hankins, Gary D.V.

AU - Longo, Monica

AU - Saade, George R.

AU - Bytautiene, Egle

N1 - Funding Information: Financial support was provided by the Department of Obstetrics and Gynecology , University of Texas Medical Branch, Galveston, TX. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2010/9

Y1 - 2010/9

N2 - Objective: We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. Study Design: Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n = 7), 30-34.9 (31.8 ± 1.2; n = 16), and ≥35 (39.5 ± 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10-10 to 10-5 mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. Results: Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. Conclusion: BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.

AB - Objective: We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. Study Design: Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n = 7), 30-34.9 (31.8 ± 1.2; n = 16), and ≥35 (39.5 ± 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10-10 to 10-5 mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. Results: Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. Conclusion: BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.

KW - indomethacin

KW - nifedipine

KW - obesity

KW - organ chamber

KW - oxytocin

KW - uterine contractility

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IS - 3

ER -

Effect of maternal body mass index on in vitro response to tocolytics in term myometrium

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