Effect of Misoprostol on immune function in elderly subjects

James Goodwin, George A. Clay

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The immunologic effects of misoprostol, an oral prostaglandin E1 (PGE1) analog, were tested in 25 individuals over age 65, compared to 25 individuals given placedo. Elderly subjects were chosen because previous in vitro studies had found an increased sensitivity to PGE of lymphocytes in older subjects. After two weeks of ingestion of misoprostol or placedo, there was a small but statistically significant decrease in IgM-rheumatois factor in the misoprostol group when compared to control and a significant decrease in the vitro sensitivity of lymphocytes from the misoprostol group to inhibition by PGE. There were no differences in total lymphocyte count, T cell or T cell subset count, delayed hypersensitivity skin test reactivity, serum immunoglobulins, or response to mitogens between the two groups. Therefore, the short term administration of an oral PGE analogue to normal elderly individuals is not associated with any detrimental effects on immunologic function after two weeks.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalProstaglandins
Volume33
Issue numberSUPPL. 1
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Misoprostol
Lymphocytes
Prostaglandins E
T-cells
Synthetic Prostaglandins
Alprostadil
Delayed Hypersensitivity
Lymphocyte Count
T-Lymphocyte Subsets
Skin Tests
Mitogens
Immunoglobulin M
Oral Administration
Immunoglobulins
Skin
Cell Count
Eating
T-Lymphocytes
Serum
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Effect of Misoprostol on immune function in elderly subjects. / Goodwin, James; Clay, George A.

In: Prostaglandins, Vol. 33, No. SUPPL. 1, 1987, p. 61-67.

Research output: Contribution to journalArticle

Goodwin, James ; Clay, George A. / Effect of Misoprostol on immune function in elderly subjects. In: Prostaglandins. 1987 ; Vol. 33, No. SUPPL. 1. pp. 61-67.
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