Effect of modulation of polymorphonuclear leukocyte migration with anti- CD18 antibody on pathogenesis of experimental otitis media in guinea pigs

Janak Patel, T. Chonmaitree, F. Schmalstieg

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Abstract

Guinea pigs were treated with anti-CD18 antibody (M8), and subsequently middle ears (ME) were infected with nontypeable Haemophilus influenzae. Forty-eight hours after infection, the ME washes of these animals had significantly lower polymorphonuclear leukocyte numbers but higher bacterial counts compared with washes of animals treated with control antibody (M11) or saline. The edema and epithelial damage of ME tissues correlated directly with polymorphonuclear leukocyte numbers and not bacterial counts.

Original languageEnglish (US)
Pages (from-to)1132-1135
Number of pages4
JournalInfection and Immunity
Volume61
Issue number3
StatePublished - 1993

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ASJC Scopus subject areas

  • Immunology

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