Effect of N-acetylchitohexaose against Candida albicans infection of tumor-bearing mice

Makiko Kobayashi, T. Watanabe, S. Suzuki, M. Suzuki

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

A water-soluble oligosaccharide, N-acetylchitohexaose (NACOS-6), was able to enhance the protective effect against Candida albicans infection in mice during the early phase of tumor-bearing. A significant decrease in the number of C. albicans cells in the kidneys of NACOS-6-treated tumor-bearing mice was observed 8 days after the fungal infection, or 15 days after the tumor transplantation. The candidacidal activity of polymorphonuclear leukocytes from NACOS-6-treated tumor-bearing mice did not differ from that of NACOS-6-untreated tumor-bearing mice. On the other hand, the candidacidal activities of both macrophages and T lymphocytes increased following administration of NACOS-6 in the early phase of tumor-bearing. The culture supernatant of T lymphocytes from NACOS-6-treated tumor-bearing mice also potentiated the candidacidal activity of casein-induced macrophages. An enhancement of natural killer cell activity of splenic lymphocytes obtained from NACOS-6-treated tumor-bearing mice was also observed.

Original languageEnglish (US)
Pages (from-to)413-426
Number of pages14
JournalMicrobiology and Immunology
Volume34
Issue number5
StatePublished - 1990
Externally publishedYes

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Candida albicans
Infection
Neoplasms
Macrophages
T-Lymphocytes
N-acetylchitohexaose
Mycoses
Caseins
Oligosaccharides
Natural Killer Cells
Neutrophils
Transplantation
Lymphocytes
Kidney
Water

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Microbiology

Cite this

Kobayashi, M., Watanabe, T., Suzuki, S., & Suzuki, M. (1990). Effect of N-acetylchitohexaose against Candida albicans infection of tumor-bearing mice. Microbiology and Immunology, 34(5), 413-426.

Effect of N-acetylchitohexaose against Candida albicans infection of tumor-bearing mice. / Kobayashi, Makiko; Watanabe, T.; Suzuki, S.; Suzuki, M.

In: Microbiology and Immunology, Vol. 34, No. 5, 1990, p. 413-426.

Research output: Contribution to journalArticle

Kobayashi, M, Watanabe, T, Suzuki, S & Suzuki, M 1990, 'Effect of N-acetylchitohexaose against Candida albicans infection of tumor-bearing mice', Microbiology and Immunology, vol. 34, no. 5, pp. 413-426.
Kobayashi, Makiko ; Watanabe, T. ; Suzuki, S. ; Suzuki, M. / Effect of N-acetylchitohexaose against Candida albicans infection of tumor-bearing mice. In: Microbiology and Immunology. 1990 ; Vol. 34, No. 5. pp. 413-426.
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