Effect of NMSO3 treatment in a murine model of human metapneumovirus infection

Leanne Spetch, Terry L. Bowlin, Antonella Casola

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg-1) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokine production, suggesting that antiviral treatment initiated at the beginning of viral infection can modify hMPV-induced disease.

Original languageEnglish (US)
Pages (from-to)2709-2712
Number of pages4
JournalJournal of General Virology
Volume89
Issue number11
DOIs
StatePublished - 2008

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Metapneumovirus
Infection
Virus Diseases
Antiviral Agents
Weight Loss
Pneumonia
Body Weight
Cytokines
Lipids
Lung

ASJC Scopus subject areas

  • Virology

Cite this

Effect of NMSO3 treatment in a murine model of human metapneumovirus infection. / Spetch, Leanne; Bowlin, Terry L.; Casola, Antonella.

In: Journal of General Virology, Vol. 89, No. 11, 2008, p. 2709-2712.

Research output: Contribution to journalArticle

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