Abstract
BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg-1) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokine production, suggesting that antiviral treatment initiated at the beginning of viral infection can modify hMPV-induced disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2709-2712 |
| Number of pages | 4 |
| Journal | Journal of General Virology |
| Volume | 89 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2008 |
ASJC Scopus subject areas
- Virology