Effect of number of human papillomavirus vaccine doses on guideline adherent cervical cytology screening among 19-26 year old females

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8 Citations (Scopus)

Abstract

Purpose: Little is known about how the number of HPV vaccine doses affect adherence to screening guidelines. This study compared adherence to cervical cancer screening by the number of HPV vaccine doses received by young women and assessed whether the specialty of vaccinating providers affected behavior. Methods: This retrospective cohort study using administrative insurance claims records included 24,964 19-26 year old women who received at least 1 injection of the HPV vaccine between January 2006 and November 2009. Vaccinated young women continuously enrolled in a nationally-representative private insurance plan for 6 months prior to and 37 months after HPV vaccine administration were included. Logistic regression was used to compare the odds of Papanicolaou (Pap) testing 3 years after vaccine initiation by number of vaccine doses and provider type. Results: In this sample, 79.3% had a Pap test 3 years following vaccine initiation. Receiving 1 (aOR: 0.60, 95% CI 0.55-0.65) or 2 (aOR: 0.80, 95% CI 0.74-0.87) doses was associated with decreased odds of Pap testing compared to 3 doses. Many young women in our sample (16.5%) were diagnosed with cervical dysplasia prior to HPV vaccination. Patients vaccinated by non-obstetrician/gynecologists were less likely to get a Pap test following vaccination. Conclusions: Women who received 1 or 2 doses of the HPV vaccine were less likely than those who received 3 doses to be screened for cervical cancer 3 years following vaccine initiation. Pediatricians and primary care physicians should convey the importance of initiating and continuing screening to HPV vaccinated patients.

Original languageEnglish (US)
Pages (from-to)134-139
Number of pages6
JournalPreventive Medicine
Volume88
DOIs
StatePublished - Jul 1 2016

Fingerprint

Papillomavirus Vaccines
Cell Biology
Guidelines
Vaccines
Papanicolaou Test
Insurance
Uterine Cervical Neoplasms
Vaccination
Uterine Cervical Dysplasia
Primary Care Physicians
Early Detection of Cancer
Cohort Studies
Retrospective Studies
Logistic Models
Injections

Keywords

  • Cervical intraepithelial neoplasia
  • Health care providers
  • Human papillomavirus
  • Papanicolaou smear
  • Papanicolaou test
  • Papillomavirus vaccines

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

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title = "Effect of number of human papillomavirus vaccine doses on guideline adherent cervical cytology screening among 19-26 year old females",
abstract = "Purpose: Little is known about how the number of HPV vaccine doses affect adherence to screening guidelines. This study compared adherence to cervical cancer screening by the number of HPV vaccine doses received by young women and assessed whether the specialty of vaccinating providers affected behavior. Methods: This retrospective cohort study using administrative insurance claims records included 24,964 19-26 year old women who received at least 1 injection of the HPV vaccine between January 2006 and November 2009. Vaccinated young women continuously enrolled in a nationally-representative private insurance plan for 6 months prior to and 37 months after HPV vaccine administration were included. Logistic regression was used to compare the odds of Papanicolaou (Pap) testing 3 years after vaccine initiation by number of vaccine doses and provider type. Results: In this sample, 79.3{\%} had a Pap test 3 years following vaccine initiation. Receiving 1 (aOR: 0.60, 95{\%} CI 0.55-0.65) or 2 (aOR: 0.80, 95{\%} CI 0.74-0.87) doses was associated with decreased odds of Pap testing compared to 3 doses. Many young women in our sample (16.5{\%}) were diagnosed with cervical dysplasia prior to HPV vaccination. Patients vaccinated by non-obstetrician/gynecologists were less likely to get a Pap test following vaccination. Conclusions: Women who received 1 or 2 doses of the HPV vaccine were less likely than those who received 3 doses to be screened for cervical cancer 3 years following vaccine initiation. Pediatricians and primary care physicians should convey the importance of initiating and continuing screening to HPV vaccinated patients.",
keywords = "Cervical intraepithelial neoplasia, Health care providers, Human papillomavirus, Papanicolaou smear, Papanicolaou test, Papillomavirus vaccines",
author = "Jacqueline Hirth and Lin, {Yu Li} and Kuo, {Yong Fang} and Abbey Berenson",
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AU - Hirth, Jacqueline

AU - Lin, Yu Li

AU - Kuo, Yong Fang

AU - Berenson, Abbey

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Purpose: Little is known about how the number of HPV vaccine doses affect adherence to screening guidelines. This study compared adherence to cervical cancer screening by the number of HPV vaccine doses received by young women and assessed whether the specialty of vaccinating providers affected behavior. Methods: This retrospective cohort study using administrative insurance claims records included 24,964 19-26 year old women who received at least 1 injection of the HPV vaccine between January 2006 and November 2009. Vaccinated young women continuously enrolled in a nationally-representative private insurance plan for 6 months prior to and 37 months after HPV vaccine administration were included. Logistic regression was used to compare the odds of Papanicolaou (Pap) testing 3 years after vaccine initiation by number of vaccine doses and provider type. Results: In this sample, 79.3% had a Pap test 3 years following vaccine initiation. Receiving 1 (aOR: 0.60, 95% CI 0.55-0.65) or 2 (aOR: 0.80, 95% CI 0.74-0.87) doses was associated with decreased odds of Pap testing compared to 3 doses. Many young women in our sample (16.5%) were diagnosed with cervical dysplasia prior to HPV vaccination. Patients vaccinated by non-obstetrician/gynecologists were less likely to get a Pap test following vaccination. Conclusions: Women who received 1 or 2 doses of the HPV vaccine were less likely than those who received 3 doses to be screened for cervical cancer 3 years following vaccine initiation. Pediatricians and primary care physicians should convey the importance of initiating and continuing screening to HPV vaccinated patients.

AB - Purpose: Little is known about how the number of HPV vaccine doses affect adherence to screening guidelines. This study compared adherence to cervical cancer screening by the number of HPV vaccine doses received by young women and assessed whether the specialty of vaccinating providers affected behavior. Methods: This retrospective cohort study using administrative insurance claims records included 24,964 19-26 year old women who received at least 1 injection of the HPV vaccine between January 2006 and November 2009. Vaccinated young women continuously enrolled in a nationally-representative private insurance plan for 6 months prior to and 37 months after HPV vaccine administration were included. Logistic regression was used to compare the odds of Papanicolaou (Pap) testing 3 years after vaccine initiation by number of vaccine doses and provider type. Results: In this sample, 79.3% had a Pap test 3 years following vaccine initiation. Receiving 1 (aOR: 0.60, 95% CI 0.55-0.65) or 2 (aOR: 0.80, 95% CI 0.74-0.87) doses was associated with decreased odds of Pap testing compared to 3 doses. Many young women in our sample (16.5%) were diagnosed with cervical dysplasia prior to HPV vaccination. Patients vaccinated by non-obstetrician/gynecologists were less likely to get a Pap test following vaccination. Conclusions: Women who received 1 or 2 doses of the HPV vaccine were less likely than those who received 3 doses to be screened for cervical cancer 3 years following vaccine initiation. Pediatricians and primary care physicians should convey the importance of initiating and continuing screening to HPV vaccinated patients.

KW - Cervical intraepithelial neoplasia

KW - Health care providers

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KW - Papanicolaou test

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