Effect of oxygen-carrying resuscitation fluids on the pharmacokinetics of antipyrine, diazepam, penicillin, and sulfamethazine in rats

J. M. Kemner, W. R. Snodgrass, S. E. Worley, G. R. Hodges, S. Melethil, C. E. Hignite, C. Tschanz

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The effects of exchange transfusion with an oxygen-carrying resuscitation fluid, Fluosol DA 20% or stroma-free hemoglobin, on the pharmacokinetics of antipyrine, diazepam, penicillin, and sulfamethazine were studied in rats. After transfusion with Fluosol DA 20% or stroma-free hemoglobin the pharmacokinetics of antipyrine, diazepam, and penicillin were unchanged when compared to control animals. After transfusion with Fluosol DA 20%, the t 1/2 of sulfamethazine was increased from 3.15 ± 0.56 to 7.65 ± 2.41 hr (p < 0.05) and the Vd was increased from 60.7 ± 17.5 to 152 ± 16 ml (p < 0.05). In contrast, after transfusion with stroma-free hemoglobin, the AUC of sulfamethazine was decreased from 129 ± 28 to 80.5 ± 27.7 μg.h.ml-1 (p < 0.05) and there was an increase in Cl from 12.2 ± 3.4 to 20.2 ± 6.0 ml.h-1 (p < 0.05) and Vd from 60.1 ± 11.8 to 132 ± 49 ml (p < 0.05). The reason for these alterations is not clear. Fluosol DA 20% and stroma-free hemoglobin may alter the acetylation of sulfamethazine.

Original languageEnglish (US)
Pages (from-to)381-400
Number of pages20
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume46
Issue number3
StatePublished - Dec 1 1984

    Fingerprint

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kemner, J. M., Snodgrass, W. R., Worley, S. E., Hodges, G. R., Melethil, S., Hignite, C. E., & Tschanz, C. (1984). Effect of oxygen-carrying resuscitation fluids on the pharmacokinetics of antipyrine, diazepam, penicillin, and sulfamethazine in rats. Research Communications in Chemical Pathology and Pharmacology, 46(3), 381-400.