Effect of pancreastatin on pancreatic endocrine and exocrine secretion

J. Ishizuka, I. Asada, G. J. Poston, F. Lluis, K. Tatemoto, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Pancreastatin is a novel peptide that was recently purified from extracts of the porcine pancreas. The present study shows that pancreastatin (10-9-10-8 M) can stimulate release of insulin from both the isolated perfused rat pancreas and from cultured rat islet cells in the presence of a low, non-insulinotropic concentration of glucose (4.2 mM). Pancreastatin (10-9 M) can also inhibit release of insulin stimulated by a high concentration of glucose (16.7 mM). Pancreastatin, at 10-8 M, can enhance glucose (8.3 mM) induced release of insulin in the static islet cell incubation. In addition, pancreastatin (10-9-10-8 M) can inhibit, in a dose-dependent fashion, cholecystokinin (CCK)-8 stimulated release of amylase from dispersed guinea pig pancreatic acini. Pancreastatin alone, however, did not affect basal release of amylase. Our study shows that pancreastatin can exert a direct effect on both pancreatic endocrine and exocrine secretion.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalPancreas
Volume4
Issue number3
StatePublished - 1989

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Insulin
Amylases
Islets of Langerhans
Glucose
Pancreas
pancreastatin
Guinea Pigs
Swine
Peptides
cholecystokinin 8

ASJC Scopus subject areas

  • Endocrinology
  • Gastroenterology

Cite this

Ishizuka, J., Asada, I., Poston, G. J., Lluis, F., Tatemoto, K., Greeley, G. H., & Thompson, J. C. (1989). Effect of pancreastatin on pancreatic endocrine and exocrine secretion. Pancreas, 4(3), 277-281.

Effect of pancreastatin on pancreatic endocrine and exocrine secretion. / Ishizuka, J.; Asada, I.; Poston, G. J.; Lluis, F.; Tatemoto, K.; Greeley, G. H.; Thompson, J. C.

In: Pancreas, Vol. 4, No. 3, 1989, p. 277-281.

Research output: Contribution to journalArticle

Ishizuka, J, Asada, I, Poston, GJ, Lluis, F, Tatemoto, K, Greeley, GH & Thompson, JC 1989, 'Effect of pancreastatin on pancreatic endocrine and exocrine secretion', Pancreas, vol. 4, no. 3, pp. 277-281.
Ishizuka J, Asada I, Poston GJ, Lluis F, Tatemoto K, Greeley GH et al. Effect of pancreastatin on pancreatic endocrine and exocrine secretion. Pancreas. 1989;4(3):277-281.
Ishizuka, J. ; Asada, I. ; Poston, G. J. ; Lluis, F. ; Tatemoto, K. ; Greeley, G. H. ; Thompson, J. C. / Effect of pancreastatin on pancreatic endocrine and exocrine secretion. In: Pancreas. 1989 ; Vol. 4, No. 3. pp. 277-281.
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AU - Greeley, G. H.

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