Effect of pancreastatin on pancreatic endocrine and exocrine secretion

Jin Ishizuka, Lsamu Asada, Graeme J. Poston, Felix Lluis, Kazuhiko Tatemoto, George H. Greeley, James C. Thompson

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Pancreastatin is a novel peptide that was recently purified from extracts of the porcine pancreas. The present study shows that pancreastatin (10~9-10-8 M) can stimulate release of insulin from both the isolated perfused rat pancreas and from cultured rat islet cells in the presence of a low, non-insulinotropic concentration of glucose (4.2 mM). Pancreastatin CIO”9 M) can also inhibit release of insulin stimulated by a high concentration of glucose (16.7 mM). Pancreastatin, at 10 8 M, can enhance glucose (8.3 mM) induced release of insulin in the static islet cell incubation. In addition, pancreastatin (10“9-10-8 M) can inhibit, in a dose-dependent fashion, cholecystokinin (CCK)-8 stimulated release of amylase from dispersed guinea pig pancreatic acini. Pancreastatin alone, however, did not affect basal release of amylase. Our study shows that pancreastatin can exert a direct effect on both pancreatic endocrine and exocrine secretion.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalPancreas
Volume4
Issue number3
DOIs
StatePublished - Jun 1989
Externally publishedYes

Keywords

  • CCK
  • Guinea pig
  • Insulin
  • Pancreatic amylase
  • Rat

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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