Effect of passive immunity on the development of a protective immune response against bovine viral diarrhea virus in calves

Julia F. Ridpath, John D. Neill, Janice Endsley, James A. Roth

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objective - To determine whether passively acquired antibodies prevent development of a protective immune response to live virus in calves. Animals - 18 calves. Procedures - Calves were caught immediately after birth and tested free of bovine viral diarrhea virus (BVDV) and serum antibodies against BVDV. Within 48 hours, 12 calves were fed colostrum that contained antibodies against BVDV and 6 calves received BVDV antibody free milk replacer. Three milk replacer fed and 6 colostrum fed calves were exposed to virulent BVDV2-1373 at 2 to 5 weeks of life when passively acquired serum antibody titers were high. After serum antibody titers against BVDV had decayed to undetectable concentrations (at 7 to 9 months of age), the 3 remaining milk replacer fed calves, 6 colostrum fed calves previously exposed to BVDV2-1373, and 6 colostrum fed calves that had not been exposed to the virus were inoculated with BVDV2-1373. Results - Passively acquired antibodies prevented clinical disease in inoculated colostrum fed calves at 2 to 5 weeks of life. Serum antibody titers did not increase in these calves following virus inoculation, and serum antibody titers decayed at the same rate as in noninoculated colostrum fed calves. Inoculated colostrum fed calves were still protected from clinical disease after serum antibody titers had decayed to nondetectable concentrations. Same age colostrum fed calves that had not been previously exposed to the virus were not protected. Conclusions and Clinical Relevance - A protective immune response was mounted in calves with passive immunity, but was not reflected by serum antibodies titers. This finding has implications for evaluating vaccine efficacy and immune status.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume64
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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Bovine Viral Diarrhea Viruses
passive immunity
Bovine viral diarrhea virus
Colostrum
Immunity
immune response
calves
Antibodies
colostrum
Bovine viral diarrhea virus 2
antibodies
Serum
Viruses
milk replacer
Milk
viruses
Vaccines

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effect of passive immunity on the development of a protective immune response against bovine viral diarrhea virus in calves. / Ridpath, Julia F.; Neill, John D.; Endsley, Janice; Roth, James A.

In: American Journal of Veterinary Research, Vol. 64, No. 1, 01.01.2003, p. 65-69.

Research output: Contribution to journalArticle

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