Effect of peptide YY on cephalic, gastric, and intestinal phases of gastric acid secretion and on the release of gastrointestinal hormones

Y. S. Guo, Pomila Singh, Guillermo Gomez, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The objective of this study was to investigate the effects of a novel gut peptide, peptide YY (PYY), on the cephalic, gastric, and intestinal phases of gastric acid secretion and to explore the mechanisms involved. The cephalic phase of gastric acid secretion, stimulated by the intravenous injection of 2-deoxyglucose (75 mg/kg), was found to be inhibited by intravenous PYY (100, 200, 400 pmol/kg · h) in a dose-related fashion. Peptide YY (200 and 400 pmol/kg · h) also resulted in a significant dose-dependent inhibition of the gastric phase of acid secretion. On the other hand, PYY (400 pmol/kg · h) failed to affect the intestinal phase of gastric acid output. Serum gastrin levels were increased on infusion of 10% liver extract into stomach, but were unaffected on instillation of liver extract into duodenum. Peptide YY did not inhibit the release of gastrin in either the gastric or intestinal phase studies. Furthermore, PYY had no significant effect on either the basal release of secretin, gastric inhibitory polypeptide, pancreatic polypeptide, or neurotensin, or on the stimulated release of pancreatic polypeptide by 2-deoxyglucose. The specific binding of gastrin to its receptors on the fundic mucosa was also unaffected by PYY. These results indicate that PYY inhibits the cephalic and gastric phases of acid secretion independently, and that its actions are not mediated by either a negative effect on gastrin release or a positive effect on the release of some of the known acid inhibitors, or by an inhibition of gastrin binding to its receptors on the fundic cells. Our present findings (in combination with our previous findings of inhibition of pentagastrin- and bethanechol-stimulated gastric acid secretion by PYY, independent of the vagal cholinergic mechanism) indicate that the action of PYY is either direct on the parietal cells or is mediated by yet another, unidentified, inhibitor.

Original languageEnglish (US)
Pages (from-to)1202-1208
Number of pages7
JournalGastroenterology
Volume92
Issue number5 I
StatePublished - 1987

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Peptide YY
Gastrointestinal Hormones
Gastric Acid
Stomach
Head
Gastrins
Liver Extracts
Deoxyglucose
Gastric Inhibitory Polypeptide
Bethanechol
Pancreatic Polypeptide
Pentagastrin
Neurotensin
Secretin
Duodenum
Intravenous Injections
Cholinergic Agents
Mucous Membrane

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effect of peptide YY on cephalic, gastric, and intestinal phases of gastric acid secretion and on the release of gastrointestinal hormones. / Guo, Y. S.; Singh, Pomila; Gomez, Guillermo; Greeley, G. H.; Thompson, J. C.

In: Gastroenterology, Vol. 92, No. 5 I, 1987, p. 1202-1208.

Research output: Contribution to journalArticle

Guo, Y. S. ; Singh, Pomila ; Gomez, Guillermo ; Greeley, G. H. ; Thompson, J. C. / Effect of peptide YY on cephalic, gastric, and intestinal phases of gastric acid secretion and on the release of gastrointestinal hormones. In: Gastroenterology. 1987 ; Vol. 92, No. 5 I. pp. 1202-1208.
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