Effect of PGE in multiple experimental models IX

in vivo effects of PGE on immune response of leucocytes to wounds

Y. L. Dong, David Herndon, T. Z. Yan, J. P. Waymack

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

There have been conflicting results obtained when comparing the in vitro with in vivo effects of prostaglandin E (PGE) on immune function. The in vitro studies have demonstrated immune suppression with PGE administration while the in vivo studies demonstrated imporved survival when utilizing infected models. To attempt to resolve this discrepancy, we evaluated the in vivo effect of PGE on host immune function utilizing multiple rat models. PGE was found to have no effect on the ability of leucocytes to infiltrate a sponge matrix wound over a 2-week period of study. PGE also failed to alter the percentage of T-lymphocyte subset populations infiltrating the sponge matrix model. There was noted to be no effect of PGE on the ability of neutrophils to chemiluminesce, or on metabolic function of lymphocytes. In conclusion, PGE does not appear to have immunosuppressive properties when studies using certain in vivo models.

Original languageEnglish (US)
Pages (from-to)132-135
Number of pages4
JournalBurns
Volume20
Issue number2
DOIs
StatePublished - 1994

Fingerprint

Prostaglandins E
Leukocytes
Theoretical Models
Wounds and Injuries
Porifera
T-Lymphocyte Subsets
Immunosuppressive Agents
Neutrophils
Lymphocytes
Population

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine
  • Surgery

Cite this

Effect of PGE in multiple experimental models IX : in vivo effects of PGE on immune response of leucocytes to wounds. / Dong, Y. L.; Herndon, David; Yan, T. Z.; Waymack, J. P.

In: Burns, Vol. 20, No. 2, 1994, p. 132-135.

Research output: Contribution to journalArticle

Dong, Y. L. ; Herndon, David ; Yan, T. Z. ; Waymack, J. P. / Effect of PGE in multiple experimental models IX : in vivo effects of PGE on immune response of leucocytes to wounds. In: Burns. 1994 ; Vol. 20, No. 2. pp. 132-135.
@article{10c4121e3e384058bc803066bd2bf3ce,
title = "Effect of PGE in multiple experimental models IX: in vivo effects of PGE on immune response of leucocytes to wounds",
abstract = "There have been conflicting results obtained when comparing the in vitro with in vivo effects of prostaglandin E (PGE) on immune function. The in vitro studies have demonstrated immune suppression with PGE administration while the in vivo studies demonstrated imporved survival when utilizing infected models. To attempt to resolve this discrepancy, we evaluated the in vivo effect of PGE on host immune function utilizing multiple rat models. PGE was found to have no effect on the ability of leucocytes to infiltrate a sponge matrix wound over a 2-week period of study. PGE also failed to alter the percentage of T-lymphocyte subset populations infiltrating the sponge matrix model. There was noted to be no effect of PGE on the ability of neutrophils to chemiluminesce, or on metabolic function of lymphocytes. In conclusion, PGE does not appear to have immunosuppressive properties when studies using certain in vivo models.",
author = "Dong, {Y. L.} and David Herndon and Yan, {T. Z.} and Waymack, {J. P.}",
year = "1994",
doi = "10.1016/S0305-4179(06)80010-0",
language = "English (US)",
volume = "20",
pages = "132--135",
journal = "Burns",
issn = "0305-4179",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Effect of PGE in multiple experimental models IX

T2 - in vivo effects of PGE on immune response of leucocytes to wounds

AU - Dong, Y. L.

AU - Herndon, David

AU - Yan, T. Z.

AU - Waymack, J. P.

PY - 1994

Y1 - 1994

N2 - There have been conflicting results obtained when comparing the in vitro with in vivo effects of prostaglandin E (PGE) on immune function. The in vitro studies have demonstrated immune suppression with PGE administration while the in vivo studies demonstrated imporved survival when utilizing infected models. To attempt to resolve this discrepancy, we evaluated the in vivo effect of PGE on host immune function utilizing multiple rat models. PGE was found to have no effect on the ability of leucocytes to infiltrate a sponge matrix wound over a 2-week period of study. PGE also failed to alter the percentage of T-lymphocyte subset populations infiltrating the sponge matrix model. There was noted to be no effect of PGE on the ability of neutrophils to chemiluminesce, or on metabolic function of lymphocytes. In conclusion, PGE does not appear to have immunosuppressive properties when studies using certain in vivo models.

AB - There have been conflicting results obtained when comparing the in vitro with in vivo effects of prostaglandin E (PGE) on immune function. The in vitro studies have demonstrated immune suppression with PGE administration while the in vivo studies demonstrated imporved survival when utilizing infected models. To attempt to resolve this discrepancy, we evaluated the in vivo effect of PGE on host immune function utilizing multiple rat models. PGE was found to have no effect on the ability of leucocytes to infiltrate a sponge matrix wound over a 2-week period of study. PGE also failed to alter the percentage of T-lymphocyte subset populations infiltrating the sponge matrix model. There was noted to be no effect of PGE on the ability of neutrophils to chemiluminesce, or on metabolic function of lymphocytes. In conclusion, PGE does not appear to have immunosuppressive properties when studies using certain in vivo models.

UR - http://www.scopus.com/inward/record.url?scp=0028255949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028255949&partnerID=8YFLogxK

U2 - 10.1016/S0305-4179(06)80010-0

DO - 10.1016/S0305-4179(06)80010-0

M3 - Article

VL - 20

SP - 132

EP - 135

JO - Burns

JF - Burns

SN - 0305-4179

IS - 2

ER -