Effect of preexisting inhalation injury on response to bacteremia in sheep

Deborah J. Dehring, Sue Doty, Ryozo Kimura, Robert C. Fader, Lillian D. Traber, David N. Herndon, Daniel L. Traber

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Inhalation injury increases the likelihood of sepsis. We tested the hypothesis that preexisting inhalation injury would diminish bacterial clearance across the pulmonary vasculature and induce greater hemodynamic response. Live Pseudomonas aeruginosa were infused centrally for one hour in three groups of awake sheep. Inh + Ps (n = 10), with a seven to 10-day-old inhalation injury; Ps-LOW (n - 8) both received 107 Ps/min; and Ps-HI (n = 9) received 5 · 107 Ps/min. for one hour. Pulmonary hypertension was more severe in Ps-HI and Inh + Ps. A hyperdynamic response with high cardiac index and low mean arterial pressure developed in Inh + Ps and Ps-HI from six to 18 hr, while in Ps-LOW, only the cardiac index was elevated at six to eight hr. The Inh + Ps and Ps-LOW groups had equivalent pulmonary artery and aortic bacterial levels, while Ps-HI had levels approximately five times higher. All groups removed bacteria efficiently in the lungs. However, preexistent inhalation injury exaggerated the pulmonary and systemic hemodynamic response.

Original languageEnglish (US)
Pages (from-to)467-471
Number of pages5
JournalJournal of Burn Care and Rehabilitation
Issue number5
StatePublished - 1988

ASJC Scopus subject areas

  • Surgery
  • General Nursing
  • Emergency Medicine
  • Rehabilitation
  • General Health Professions


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