Effect of prostaglandin E on immune function in normal healthy volunteers

J. P. Waymack, G. Klimpel, J. Haithcoat, R. L. Rutan, David Herndon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Prostaglandin E (PGE) has been hypothesized to be the endogenous metabolite that results in the immunosuppression seen in patients with tumor and trauma. This has resulted in multiple investigators proposing that administration of PGE inhibitors, such as aspirin and indomethacin, might improve immune function in such patients. We administered a long acting PGE analog, misoprostol, to nine normal healthy volunteers for five days and assayed immune function before and after therapy. The PGE analog improved lymphocyte blastogenesis and increased tumor necrosis factor production. The PGE analog also resulted in the volunteers having symptoms similar to those seen in patients with sepsis. The results of these studies indicate that elevated levels of PGE do not seem to result in impairment of immune function, but may be the endogenous metabolite responsible for the symptologic factors seen in infected patients.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalSurgery Gynecology and Obstetrics
Volume175
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Synthetic Prostaglandins E
Prostaglandins E
Healthy Volunteers
Prostaglandin Antagonists
Misoprostol
Lymphocyte Activation
Indomethacin
Immunosuppression
Aspirin
Volunteers
Sepsis
Tumor Necrosis Factor-alpha
Research Personnel
Lymphocytes
Wounds and Injuries
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Surgery

Cite this

Waymack, J. P., Klimpel, G., Haithcoat, J., Rutan, R. L., & Herndon, D. (1992). Effect of prostaglandin E on immune function in normal healthy volunteers. Surgery Gynecology and Obstetrics, 175(4), 329-332.

Effect of prostaglandin E on immune function in normal healthy volunteers. / Waymack, J. P.; Klimpel, G.; Haithcoat, J.; Rutan, R. L.; Herndon, David.

In: Surgery Gynecology and Obstetrics, Vol. 175, No. 4, 1992, p. 329-332.

Research output: Contribution to journalArticle

Waymack, JP, Klimpel, G, Haithcoat, J, Rutan, RL & Herndon, D 1992, 'Effect of prostaglandin E on immune function in normal healthy volunteers', Surgery Gynecology and Obstetrics, vol. 175, no. 4, pp. 329-332.
Waymack JP, Klimpel G, Haithcoat J, Rutan RL, Herndon D. Effect of prostaglandin E on immune function in normal healthy volunteers. Surgery Gynecology and Obstetrics. 1992;175(4):329-332.
Waymack, J. P. ; Klimpel, G. ; Haithcoat, J. ; Rutan, R. L. ; Herndon, David. / Effect of prostaglandin E on immune function in normal healthy volunteers. In: Surgery Gynecology and Obstetrics. 1992 ; Vol. 175, No. 4. pp. 329-332.
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