Effect of race on outcome after kidney and kidney-pancreas transplantation in type 1 diabetic patients

Viken Douzdjian, S. Shanmuga Bhaskar, Prabakar K. Baliga, Kristene Gugliuzza, P. R. Rajagopalan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE - The racial impact on graft outcome is not well defined in diabetic recipients. The purpose of this study is to analyze our experience with kidney-alone (KA) and kidney-pancreas (KP) transplantation in type 1 diabetic recipients and evaluate the impact of racial disparity on outcome. RESEARCH DESIGN AND METHODS - The records of 217 kidney transplants (118 KA, 99 KP) performed on type 1 diabetic patients between 1985 and 1995 at the Medical University of South Carolina and the University of Texas Medical Branch were reviewed. RESULTS - A total of 53 (31%) white patients and 15 (33%) black patients experienced at least one episode of biopsy-proven acute rejection of the renal graft (NS). Patient survival at 1, 2, and 5 years was similar in white (92, 87, 69%) and black (93, 91, 69%) patients (NS). Kidney graft survival at 1, 2, and 5 years in the KA group was 72, 62, and 42% in blacks, compared with 79, 76, and 53% in whites (NS). Kidney graft survival at 1, 2, and 5 years in the KP group was 92, 92, and 74% in blacks, compared with 83, 77, and 58% in whites (NS). Pancreas graft survival at 1, 2, and 5 years was 81, 81, and 81% in blacks, compared with 81, 75, and 62% in whites (NS). Cox regression analysis revealed that donor age ≤40 years increased the risk of renal graft failure 6.2-fold (P = 0.0001), whereas the addition of a pancreas transplant to a kidney and a living-related transplant decreased the risk of failure of the kidney grab 0.2 (P = 0.005) and 0.1 times (P = 0.005). CONCLUSIONS - Our results suggest that when compared with whites, there may be a trend toward an improved kidney and pancreas graft outcome in blacks undergoing KP transplants. These findings suggest that diabetes may override the risk factors that account for the pronounced disparity in outcome observed between nondiabetic white and black recipients.

Original languageEnglish (US)
Pages (from-to)1310-1314
Number of pages5
JournalDiabetes Care
Volume20
Issue number8
StatePublished - Aug 1997

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Pancreas Transplantation
Kidney Transplantation
Kidney
Pancreas
Transplants
Graft Survival
Renal Insufficiency
Graft Rejection
Research Design

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Douzdjian, V., Bhaskar, S. S., Baliga, P. K., Gugliuzza, K., & Rajagopalan, P. R. (1997). Effect of race on outcome after kidney and kidney-pancreas transplantation in type 1 diabetic patients. Diabetes Care, 20(8), 1310-1314.

Effect of race on outcome after kidney and kidney-pancreas transplantation in type 1 diabetic patients. / Douzdjian, Viken; Bhaskar, S. Shanmuga; Baliga, Prabakar K.; Gugliuzza, Kristene; Rajagopalan, P. R.

In: Diabetes Care, Vol. 20, No. 8, 08.1997, p. 1310-1314.

Research output: Contribution to journalArticle

Douzdjian, V, Bhaskar, SS, Baliga, PK, Gugliuzza, K & Rajagopalan, PR 1997, 'Effect of race on outcome after kidney and kidney-pancreas transplantation in type 1 diabetic patients', Diabetes Care, vol. 20, no. 8, pp. 1310-1314.
Douzdjian, Viken ; Bhaskar, S. Shanmuga ; Baliga, Prabakar K. ; Gugliuzza, Kristene ; Rajagopalan, P. R. / Effect of race on outcome after kidney and kidney-pancreas transplantation in type 1 diabetic patients. In: Diabetes Care. 1997 ; Vol. 20, No. 8. pp. 1310-1314.
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abstract = "OBJECTIVE - The racial impact on graft outcome is not well defined in diabetic recipients. The purpose of this study is to analyze our experience with kidney-alone (KA) and kidney-pancreas (KP) transplantation in type 1 diabetic recipients and evaluate the impact of racial disparity on outcome. RESEARCH DESIGN AND METHODS - The records of 217 kidney transplants (118 KA, 99 KP) performed on type 1 diabetic patients between 1985 and 1995 at the Medical University of South Carolina and the University of Texas Medical Branch were reviewed. RESULTS - A total of 53 (31{\%}) white patients and 15 (33{\%}) black patients experienced at least one episode of biopsy-proven acute rejection of the renal graft (NS). Patient survival at 1, 2, and 5 years was similar in white (92, 87, 69{\%}) and black (93, 91, 69{\%}) patients (NS). Kidney graft survival at 1, 2, and 5 years in the KA group was 72, 62, and 42{\%} in blacks, compared with 79, 76, and 53{\%} in whites (NS). Kidney graft survival at 1, 2, and 5 years in the KP group was 92, 92, and 74{\%} in blacks, compared with 83, 77, and 58{\%} in whites (NS). Pancreas graft survival at 1, 2, and 5 years was 81, 81, and 81{\%} in blacks, compared with 81, 75, and 62{\%} in whites (NS). Cox regression analysis revealed that donor age ≤40 years increased the risk of renal graft failure 6.2-fold (P = 0.0001), whereas the addition of a pancreas transplant to a kidney and a living-related transplant decreased the risk of failure of the kidney grab 0.2 (P = 0.005) and 0.1 times (P = 0.005). CONCLUSIONS - Our results suggest that when compared with whites, there may be a trend toward an improved kidney and pancreas graft outcome in blacks undergoing KP transplants. These findings suggest that diabetes may override the risk factors that account for the pronounced disparity in outcome observed between nondiabetic white and black recipients.",
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T1 - Effect of race on outcome after kidney and kidney-pancreas transplantation in type 1 diabetic patients

AU - Douzdjian, Viken

AU - Bhaskar, S. Shanmuga

AU - Baliga, Prabakar K.

AU - Gugliuzza, Kristene

AU - Rajagopalan, P. R.

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N2 - OBJECTIVE - The racial impact on graft outcome is not well defined in diabetic recipients. The purpose of this study is to analyze our experience with kidney-alone (KA) and kidney-pancreas (KP) transplantation in type 1 diabetic recipients and evaluate the impact of racial disparity on outcome. RESEARCH DESIGN AND METHODS - The records of 217 kidney transplants (118 KA, 99 KP) performed on type 1 diabetic patients between 1985 and 1995 at the Medical University of South Carolina and the University of Texas Medical Branch were reviewed. RESULTS - A total of 53 (31%) white patients and 15 (33%) black patients experienced at least one episode of biopsy-proven acute rejection of the renal graft (NS). Patient survival at 1, 2, and 5 years was similar in white (92, 87, 69%) and black (93, 91, 69%) patients (NS). Kidney graft survival at 1, 2, and 5 years in the KA group was 72, 62, and 42% in blacks, compared with 79, 76, and 53% in whites (NS). Kidney graft survival at 1, 2, and 5 years in the KP group was 92, 92, and 74% in blacks, compared with 83, 77, and 58% in whites (NS). Pancreas graft survival at 1, 2, and 5 years was 81, 81, and 81% in blacks, compared with 81, 75, and 62% in whites (NS). Cox regression analysis revealed that donor age ≤40 years increased the risk of renal graft failure 6.2-fold (P = 0.0001), whereas the addition of a pancreas transplant to a kidney and a living-related transplant decreased the risk of failure of the kidney grab 0.2 (P = 0.005) and 0.1 times (P = 0.005). CONCLUSIONS - Our results suggest that when compared with whites, there may be a trend toward an improved kidney and pancreas graft outcome in blacks undergoing KP transplants. These findings suggest that diabetes may override the risk factors that account for the pronounced disparity in outcome observed between nondiabetic white and black recipients.

AB - OBJECTIVE - The racial impact on graft outcome is not well defined in diabetic recipients. The purpose of this study is to analyze our experience with kidney-alone (KA) and kidney-pancreas (KP) transplantation in type 1 diabetic recipients and evaluate the impact of racial disparity on outcome. RESEARCH DESIGN AND METHODS - The records of 217 kidney transplants (118 KA, 99 KP) performed on type 1 diabetic patients between 1985 and 1995 at the Medical University of South Carolina and the University of Texas Medical Branch were reviewed. RESULTS - A total of 53 (31%) white patients and 15 (33%) black patients experienced at least one episode of biopsy-proven acute rejection of the renal graft (NS). Patient survival at 1, 2, and 5 years was similar in white (92, 87, 69%) and black (93, 91, 69%) patients (NS). Kidney graft survival at 1, 2, and 5 years in the KA group was 72, 62, and 42% in blacks, compared with 79, 76, and 53% in whites (NS). Kidney graft survival at 1, 2, and 5 years in the KP group was 92, 92, and 74% in blacks, compared with 83, 77, and 58% in whites (NS). Pancreas graft survival at 1, 2, and 5 years was 81, 81, and 81% in blacks, compared with 81, 75, and 62% in whites (NS). Cox regression analysis revealed that donor age ≤40 years increased the risk of renal graft failure 6.2-fold (P = 0.0001), whereas the addition of a pancreas transplant to a kidney and a living-related transplant decreased the risk of failure of the kidney grab 0.2 (P = 0.005) and 0.1 times (P = 0.005). CONCLUSIONS - Our results suggest that when compared with whites, there may be a trend toward an improved kidney and pancreas graft outcome in blacks undergoing KP transplants. These findings suggest that diabetes may override the risk factors that account for the pronounced disparity in outcome observed between nondiabetic white and black recipients.

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