Effect of Recombinant Human Interleukin 4 on Human Monocyte Activity

Melissa M. Hudson, Rebecca D. Knowles, John S. Snyder, Eugenie S. Kleinerman, Melissa M. Hudson, Eugenie S. Kleinerman, Avi B. Markowitz, Jordan U. Gutterman

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Recombinant human interleukin 4 (rhuIL-4), a lymphokine that re portedly stimulates tumoricidal activity in mouse macrophages, is cur rently undergoing clinical studies to determine its efficacy in the treatment of cancer. IL-4 is known to participate with other cytokines to regulare growth and differentiation of various hematopoietic cells as well as modulate the immune response. Little is known about the effect of rhuIL 4 on human monocyte tumoricidal activity. The purpose of these studies was to examine the effect of rhuIL-4 on human peripheral blood mono cytes. Peripheral blood monocytes isolated from normal donors failed to demonstrate tumoricidal activity or interleukin 1 secretion after treatment with rhuIL-4 in vitro. Furthermore, monocyte-mediated cytotoxicity induced by recombinant human γ-interferon plus muramyl dipeptide was suppressed in a dose-dependent manner by rhuIL-4. This reduction in cytotoxicity corresponded to a reduction in IL-1 production and secretion Further investigation of rhuIL-4 and its role in the cytokine network is necessary for the development of effective immunotherapy in cancer patients.

Original languageEnglish (US)
Pages (from-to)3154-3158
Number of pages5
JournalCancer Research
Issue number11
StatePublished - Jun 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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