Effect of Recombinant Human Interleukin 4 on Human Monocyte Activity

Melissa M. Hudson, Rebecca D. Knowles, John S. Snyder, Eugenie S. Kleinerman, Melissa M. Hudson, Eugenie S. Kleinerman, Avi B. Markowitz, Jordan U. Gutterman

    Research output: Contribution to journalArticle

    17 Scopus citations

    Abstract

    Recombinant human interleukin 4 (rhuIL-4), a lymphokine that re portedly stimulates tumoricidal activity in mouse macrophages, is cur rently undergoing clinical studies to determine its efficacy in the treatment of cancer. IL-4 is known to participate with other cytokines to regulare growth and differentiation of various hematopoietic cells as well as modulate the immune response. Little is known about the effect of rhuIL 4 on human monocyte tumoricidal activity. The purpose of these studies was to examine the effect of rhuIL-4 on human peripheral blood mono cytes. Peripheral blood monocytes isolated from normal donors failed to demonstrate tumoricidal activity or interleukin 1 secretion after treatment with rhuIL-4 in vitro. Furthermore, monocyte-mediated cytotoxicity induced by recombinant human γ-interferon plus muramyl dipeptide was suppressed in a dose-dependent manner by rhuIL-4. This reduction in cytotoxicity corresponded to a reduction in IL-1 production and secretion Further investigation of rhuIL-4 and its role in the cytokine network is necessary for the development of effective immunotherapy in cancer patients.

    Original languageEnglish (US)
    Pages (from-to)3154-3158
    Number of pages5
    JournalCancer Research
    Volume50
    Issue number11
    StatePublished - Jun 1 1990

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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  • Cite this

    Hudson, M. M., Knowles, R. D., Snyder, J. S., Kleinerman, E. S., Hudson, M. M., Kleinerman, E. S., Markowitz, A. B., & Gutterman, J. U. (1990). Effect of Recombinant Human Interleukin 4 on Human Monocyte Activity. Cancer Research, 50(11), 3154-3158.