TY - JOUR
T1 - Effect of silver nanoparticles upon the myocardial and coronary vascular function in isolated and perfused diabetic rat hearts
AU - Ramirez-Lee, Manuel Alejandro
AU - Espinosa-Tanguma, Ricardo
AU - Mejía-Elizondo, Rebeca
AU - Medina-Hernández, Alejandra
AU - Martinez-Castañon, Gabriel Alejandro
AU - Gonzalez, Carmen
N1 - Funding Information:
This work was supported by Consejo Nacional de Ciencia y Tecnologia through the fellowship of Ramirez-Lee (318669) and the grants C15-FAI-04-33.33; C15-PIFI-06-02.02 and C16-PIFI-09-08.08.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/11
Y1 - 2017/11
N2 - Silver nanoparticles (AgNPs) are promising antibacterial nanomaterials for diagnostic and treatment of diabetes. However, toxicity and adverse cardiac responses induced by AgNPs related to nitric oxide (NO) and oxidative stress (OS) are described. Moreover, little is known about the diabetes influence upon AgNPs-toxicity. The aim of this work was to evaluate cardiovascular function in response to AgNPs through measuring perfusion pressure (PP) and left ventricle pressure (LVP), using perfused hearts from streptozotocin (STZ)-induced diabetic rats and identify the role of NO and OS. High concentrations but not the lower concentrations of AgNPs, promotes increases in PP and LVP, as well as increased OS. Additionally, diabetes alters the classic effects of phenylephrine (Phe) and acetylcholine (ACh). These data suggest that diabetes may intensify AgNPs-cardiotoxicity. Nevertheless, the precise mechanism of action is still under elucidation.
AB - Silver nanoparticles (AgNPs) are promising antibacterial nanomaterials for diagnostic and treatment of diabetes. However, toxicity and adverse cardiac responses induced by AgNPs related to nitric oxide (NO) and oxidative stress (OS) are described. Moreover, little is known about the diabetes influence upon AgNPs-toxicity. The aim of this work was to evaluate cardiovascular function in response to AgNPs through measuring perfusion pressure (PP) and left ventricle pressure (LVP), using perfused hearts from streptozotocin (STZ)-induced diabetic rats and identify the role of NO and OS. High concentrations but not the lower concentrations of AgNPs, promotes increases in PP and LVP, as well as increased OS. Additionally, diabetes alters the classic effects of phenylephrine (Phe) and acetylcholine (ACh). These data suggest that diabetes may intensify AgNPs-cardiotoxicity. Nevertheless, the precise mechanism of action is still under elucidation.
KW - Diabetic rats
KW - Nitric oxide
KW - Oxidative stress
KW - Silver nanoparticles
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U2 - 10.1016/j.nano.2017.07.007
DO - 10.1016/j.nano.2017.07.007
M3 - Article
C2 - 28756091
AN - SCOPUS:85028727969
SN - 1549-9634
VL - 13
SP - 2587
EP - 2596
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
IS - 8
ER -