Effect of silver nanoparticles upon the myocardial and coronary vascular function in isolated and perfused diabetic rat hearts

Manuel Alejandro Ramirez-Lee; Ricardo Espinosa-Tanguma; Rebeca Mejía-Elizondo; Alejandra Medina-Hernández; Gabriel Alejandro Martinez-Castañon; Carmen Gonzalez

doi:10.1016/j.nano.2017.07.007

Effect of silver nanoparticles upon the myocardial and coronary vascular function in isolated and perfused diabetic rat hearts

Manuel Alejandro Ramirez-Lee, Ricardo Espinosa-Tanguma, Rebeca Mejía-Elizondo, Alejandra Medina-Hernández, Gabriel Alejandro Martinez-Castañon, Carmen Gonzalez

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Silver nanoparticles (AgNPs) are promising antibacterial nanomaterials for diagnostic and treatment of diabetes. However, toxicity and adverse cardiac responses induced by AgNPs related to nitric oxide (NO) and oxidative stress (OS) are described. Moreover, little is known about the diabetes influence upon AgNPs-toxicity. The aim of this work was to evaluate cardiovascular function in response to AgNPs through measuring perfusion pressure (PP) and left ventricle pressure (LVP), using perfused hearts from streptozotocin (STZ)-induced diabetic rats and identify the role of NO and OS. High concentrations but not the lower concentrations of AgNPs, promotes increases in PP and LVP, as well as increased OS. Additionally, diabetes alters the classic effects of phenylephrine (Phe) and acetylcholine (ACh). These data suggest that diabetes may intensify AgNPs-cardiotoxicity. Nevertheless, the precise mechanism of action is still under elucidation.

Original language	English (US)
Pages (from-to)	2587-2596
Number of pages	10
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	13
Issue number	8
DOIs	https://doi.org/10.1016/j.nano.2017.07.007
State	Published - Nov 2017
Externally published	Yes

Keywords

Diabetic rats
Nitric oxide
Oxidative stress
Silver nanoparticles

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
General Materials Science
Pharmaceutical Science

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10.1016/j.nano.2017.07.007

Cite this

Ramirez-Lee, M. A., Espinosa-Tanguma, R., Mejía-Elizondo, R., Medina-Hernández, A., Martinez-Castañon, G. A., & Gonzalez, C. (2017). Effect of silver nanoparticles upon the myocardial and coronary vascular function in isolated and perfused diabetic rat hearts. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(8), 2587-2596. https://doi.org/10.1016/j.nano.2017.07.007

Effect of silver nanoparticles upon the myocardial and coronary vascular function in isolated and perfused diabetic rat hearts. / Ramirez-Lee, Manuel Alejandro; Espinosa-Tanguma, Ricardo; Mejía-Elizondo, Rebeca et al.
In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 13, No. 8, 11.2017, p. 2587-2596.

Research output: Contribution to journal › Article › peer-review

Ramirez-Lee, MA, Espinosa-Tanguma, R, Mejía-Elizondo, R, Medina-Hernández, A, Martinez-Castañon, GA & Gonzalez, C 2017, 'Effect of silver nanoparticles upon the myocardial and coronary vascular function in isolated and perfused diabetic rat hearts', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 13, no. 8, pp. 2587-2596. https://doi.org/10.1016/j.nano.2017.07.007

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Effect of silver nanoparticles upon the myocardial and coronary vascular function in isolated and perfused diabetic rat hearts

Abstract

Keywords

ASJC Scopus subject areas

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